This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Original Articles

Combining Bupropion SR With Venlafaxine, Paroxetine, or Fluoxetine: A Preliminary Report on Pharmacokinetic, Therapeutic, and Sexual Dysfunction Effects

Sidney H. Kennedy, Sonia M. McCann, Mario Masellis, Roger S. McIntyre, Joel Raskin, Gordon McKay, and Glen B. Baker

Published: March 1, 2002

Article Abstract

Background: This study was designed to evaluate the effect of combining bupropion sustained release (SR) with venlafaxine, paroxetine, or fluoxetine in patients who reported unacceptable sexual dysfunction when treated with monotherapy with the latter 3 agents.

Method: Following a minimum of 6 weeks of antidepressant treatment with a selective serotonin reuptake inhibitor (SSRI) or venlafaxine (a serotonin-norepinephrine reuptake inhibitor), eligible subjects received a further 8 weeks of monitored combination therapy with bupropion SR at a dose of 150 mg/day with no alterations to index antidepressant dosing.

Results: There was a clinically significant benefit in 14 (78%) of 18 partial responders or nonresponders, and 33% (N=6) achieved a full response (c2=8.06, df=2, p=.017). Sexual dysfunction, particularly a decrease in orgasmic delay, was also significantly improved with combination therapy (men: paired t=-2.1, df=6, p=.08; women: paired t=-3.0, df=7, p=.02). Plasma monitoring of drugs and their metabolites revealed a statistically significant increase in venlafaxine levels (F=6.89, df=4,24; p=.001) accompanied by a decrease in O-desmethylvenlafaxine (F=14.26; df=4,24; p<.0005)

Conclusion: Bupropion had an effect on the pharmacokinetics of venlafaxine but not those of the SSRIs. Further investigation of combination treatments under randomized, double-blind conditions is recommended.

Volume: 63

Quick Links: Depression (MDD)

Continue Reading…

Subscribe to read the entire article

$40.00

Buy this Article as a PDF

Sign-up to stay
up-to-date today!

SUBSCRIBE

Already registered? Sign In

Clinical and Practical Psychopharmacology

Skeletal and Dental Fractures Associated With Electroconvulsive Therapy

Recent data suggest the risk of skeletal or dental fracture with ECT may be as low as...

Read More...