This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.


Drug Interactions—Friend or Foe?

James W. Jefferson, M.D.

Published: June 1, 1998

Article Abstract

An explosion of knowledge about interactions of drugs with other drugs and with foods threatensto inundate clinicians. This review provides a better understanding of the cytochrome P450 systemwith a focus on those enzymes most involved in drug metabolism. Emphasis is placed on antidepressantmedications, how they are metabolized by the P450 system, and how they alter the metabolism ofother drugs. The role of antidepressants in precipitating the serotonin syndrome is also discussed.

Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Volume: 59

Quick Links: Depression (MDD)

Sign-up to stay
up-to-date today!


Already registered? Sign In

Letter to the Editor

Stigma Kills Psychiatric Patients and Is Now Killing Clinical Research Too

Robert M. Post, MD, argues that NIMH should abandon the RDoC framework and restore funding for clinical...