This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Articles

Possible Neurobiological Mechanisms Underlying Faster Onset of Antidepressant Action

Article Abstract

All antidepressant drugs have a delayed onset of action. There is, however, evidence that someagents may attenuate depressive symptoms more rapidly than others. The present review examines themechanisms by which selective serotonin reuptake inhibitors, the dual 5-HT norepinephrine reuptakeinhibitor venlafaxine, and the α2-adrenoceptor antagonist mirtazapine alter 5-HT and/or norepinephrineneurotransmission. Particular attention is given to the time course with which these effects manifestthemselves in relation to the possibility that these 3 types of drugs may act more rapidly, or exerta greater antidepressant action, than other agents. Based on the effects of antidepressant drugs presentlyavailable, strategies to accelerate or augment the antidepressant response are described, some ofwhich have already been examined in patients.


Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 62

Quick Links: Depression (MDD)