A Placebo-Controlled, Crossover Trial of Granisetron in SRI-Induced Sexual Dysfunction

Erik B. Nelson, Vikram N. Shah, Jeffrey A. Welge, and Paul E. Keck, Jr.

Published: June 1, 2001

Article Abstract

Background: Sexual side effects are commonlyassociated with serotonin reuptake inhibitor (SRI) therapy. Themechanism underlying SRI-induced sexual dysfunction has beenhypothesized to be mediated by direct serotonergic effects.Evidence from open-label reports suggests that cyproheptadine,nefazodone, mirtazapine, and mianserin, which block one or moreserotonin receptors, may reverse sexual side effects. The currentstudy was a prospective, randomized, crossover trial comparinggranisetron, a serotonin-3 antagonist, with placebo inoutpatients who developed sexual dysfunction during SRItreatment.

Method: Thirty-one outpatients who werecurrently experiencing sexual dysfunction associated with SRIswere randomly assigned to double-blind treatment with granisetron(1-1.5 mg) or placebo for use 1 to 2 hours prior to sexualactivity. Patients rated sexual symptoms after each trial usingthe Sexual Side Effect Scale (SSES). After 4 trials of themedication, patients crossed over to the other treatment for 4more trials.

Results: Twenty patients received at least 1dose of placebo and granisetron. Analysis by repeated-measuresanalysis of variance showed no significant effects of granisetronrelative to placebo. Significant improvement between baseline andtreatment-phase SSES scores was observed for both granisetron (p= .0004) and placebo (p = .0081). The study medication wasgenerally well tolerated.

Conclusion: The results of this study do notsupport the efficacy of granisetron (1-2 mg) in the treatment ofSRI-associated sexual side effects. A significant placeboresponse may be associated with the treatment of SRI-inducedsexual dysfunction.

Volume: 62

Quick Links: Depression (MDD) , Sexual Dysfunction

Continue Reading…

Subscribe to read the entire article

$40.00

Buy this Article as a PDF

References

Sign-up to stay
up-to-date today!

SUBSCRIBE

Already registered? Sign In

Original Research

Frontothalamic Circuit Abnormalities in Patients With Bipolar Depression and Suicide Attempts

To identify potential markers for suicide risk, this fMRI study looked at neural activity in bipolar depression...

Read More...