This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Articles

The Treatment of Psychotic Depression

William Coryell, M.D.

Published: April 1, 1998

Article Abstract

Psychotic depression is marked by increased severity, longer episodes, greater incapacity, and alower likelihood of placebo response. Psychotic features often recur in subsequent episodes andinterepisode intervals are shorter when psychotic features have been previously present. Among thetreatment options for psychotic depression, electroconvulsive therapy is particularly effective. Conventionalpharmacotherapy consists of tricyclic antidepressants combined with antipsychotics; recoverywith tricyclic antidepressant monotherapy is less likely. Serotonin selective reuptake inhibitorsmay prove useful but the relevant literature is scant. Pharmacokinetic interactions are likely in combinationtreatment, as are side effects that may mimic the underlying condition. Little is known regardingthe importance of antipsychotics to maintenance therapy.


Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Volume: 59

Quick Links: Depression (MDD)

Sign-up to stay
up-to-date today!

SUBSCRIBE

Already registered? Sign In

Original Research

Prevalence and Correlates of Obsessive-Compulsive Symptoms in Individuals With Schizophrenia, Schizoaffective Disorder, or Bipolar Disorder

Prevalence and correlates of obsessive-compulsive symptoms and OCD were identified from the case records of over 22,500...

Read More...