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Letters To the Editor

Higher Levels of Anger and Aggressiveness in Major Depressive Disorder Than in Anxiety and Somatoform Disorders

Article Abstract

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Sir: Leung and colleagues1, recently reported on the pretreatment of patients undergoing electroconvulsive therapy (ECT)with ibuprofen in an apparently successful attempt at reducing the incidence of post-ECT headache. One of the more interesting findings from their data, however, goes unmentioned in their discussion of the otherwise useful study. Table 1(p552) in their article compares the placebo group and the ibuprofen group on a number of factors, one of which is seizure duration. Although the difference between the 2 groups did not meet the authors’ a priori significance level of .05, it did produce an interesting p value of .16 with those patients given ibuprofen, 600 mg, 90 minutes prior to the ECT treatment averaging a seizure duration almost 5 seconds longer compared with those given placebo.


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