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Case Report

Intranasal Ketamine Treatment in an Adult With Autism Spectrum Disorder

Logan K. Wink, MD; Anne M. O†Melia, MD; Rebecca C. Shaffer, PsyD; Ernest Pedapati, MD; Katherine Friedmann, RN; Tori Schaefer, PhD; and Craig A. Erickson, MD

Published: August 26, 2014

Article Abstract

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Ketamine, a noncompetitive antagonist at the N-methyl-d-aspartate glutamate receptor, has been demonstrated in controlled clinical trials to rapidly decrease symptoms of depression in adults via intravenous infusion and has demonstrated promising results in an uncontrolled trial of intranasal infusion in adolescents with bipolar disorder. Other glutamatergic modulators, including d-cycloserine, amantadine, and memantine, have been the focus of drug development targeting core social impairment in autism spectrum disorder (ASD). However, to date, there have been no reports of ketamine treatment in individuals with ASD.

Volume: 75

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