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The Naturalistic Course of Pharmacologic Treatment of Children With Maniclike Symptoms: A Systematic Chart Review

Joseph Biederman, Eric Mick, Jeff Q. Bostic, Jefferson Prince, Jeff Daly, Timothy E. Wilens, Thomas Spencer, Jennifer Garcia-Jetton, Ronald Russell, Janet Wozniak, and Stephen V. Faraone

Published: November 15, 1998

Article Abstract

Objective: To assess the effectiveness of mood stabilizers in treating maniclike symptoms in children.

Method: Subjects were consecutively referred pediatric patients who, at initial intake, satisfied DSM-III-R criteria for mania on a structured diagnostic interview. We systematically reviewed their clinical records to assess (1)the course of maniclike symptoms and (2)all medications prescribed at each follow-up visit. Survival analysis was used to determine the effect of mood stabilizers and other medications on the course of maniclike symptoms.

Results: Of the 59 subjects meeting criteria for mania, 44 (75%) exhibited evidence of maniclike symptoms during follow-up. The occurrence of manic symptoms significantly predicted the subsequent prescription of mood stabilizers (rate ratio = 2.9, 95% confidence interval [CI] = 1.6 to 5.5), and use of mood stabilizers predicted decreases in manic symptoms (rate ratio = 4.9, 95% CI = 1.2 to 20.8). However, improvement was slow and associated with a substantial risk for relapse.

Conclusion: Mood stabilizers were frequently used in children with maniclike symptoms, and their use was associated with significant improvement of maniclike symptoms, whereas use of antidepressant, antipsychotic, and stimulant medications was not.

Volume: 59

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