This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Original Articles

Methylphenidate Treatment for Cocaine Abusers With Adult Attention-Deficit/Hyperactivity Disorder: A Pilot Study

Frances R. Levin, Suzette M. Evans, David M. McDowell, and Herbert D. Kleber

Published: June 15, 1998

Article Abstract

Background: Attention-deficit/hyperactivitydisorder (ADHD) is common among cocaine abusers seekingtreatment. This open trial was carried out to assess the efficacyof sustained-release methylphenidate for the treatment of cocaineabuse among individuals with ADHD.

Method: Twelve patients who met DSM-IVdiagnostic criteria for adult ADHD and cocaine dependence wereentered into a 12-week trial of divided daily doses ofsustained-release methylphenidate ranging from 40 to 80 mg. Inaddition to the pharmacotherapy, patients also receivedindividual weekly relapse prevention therapy. Individuals wereassessed weekly for ADHD symptoms; vital signs and urinetoxicologies were obtained 3 times a week.

Results: Of the 12 patients entered, 10completed at least 8 weeks of the study and 8 completed theentire study. Using both a semistructured clinical interview anda self-report assessment, patients reported reductions inattention difficulties, hyperactivity, and impulsivity.Self-reported cocaine use and craving decreased significantly.More importantly, cocaine use, confirmed by urine toxicologies,also decreased significantly.

Conclusion: These preliminary data suggest thatunder close supervision, the combined intervention ofsustained-release methylphenidate and relapse prevention therapymay be effective in treating individuals with both adult ADHD andcocaine dependence.

Volume: 59

Quick Links: ADHD , Neurodevelopmental

Continue Reading…

Subscribe to read the entire article

$40.00

Buy this Article as a PDF

Sign-up to stay
up-to-date today!

SUBSCRIBE

Already registered? Sign In

Case Report

Safety and Tolerability of Concomitant Intranasal Esketamine Treatment With Irreversible, Nonselective MAOIs: A Case Series

Three cases suggest that concomitant use of intranasal esketamine with an irreversible, nonselective MAOI is safe in...

Read More...