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Pharmacology of Antidepressants: Focus on Nefazodone

C. Lindsay DeVane, PharmD; Dale R. Grothe, PharmD, BCPP; and Sherry L. Smith, PharmD, BCPP

Published: January 1, 2002

Article Abstract

The past decade has witnessed the introduction of a diverse group of antidepressants from a variety of distinct chemical classes, each with their own specificity for neurochemical transmitters, receptors, and cytochrome P450 isozymes. This review focuses on nefazodone, a distinct antidepressant with efficacy for the treatment of depression with depression-related anxiety symptoms, an established tolerability profile, and a multimodal mechanism of action. Relevant pharmacologic and pharmacodynamic effects are summarized that support nefazodone as an attractive choice for both the shortand long-term treatment of depression.

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