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Pharmacotherapy of Posttraumatic Stress Disorder: Treatment Options, Long-Term Follow-Up, and Predictors of Outcome

Jonathan R. T. Davidson, MD

Published: May 31, 2000

Article Abstract

Posttraumatic stress disorder (PTSD) is a prevalent and disabling condition. Treatment is essentialto reduce symptoms, increase the patient’s functioning and well-being, and reduce comorbidity withother psychological disorders. Evidence suggests that psychopharmacologic therapy can be effectivein PTSD. This article considers clinical data for various pharmacologic treatment options for PTSD;in particular, several recent studies of selective serotonin reuptake inhibitors are examined. The longtermeffects of pharmacotherapy and issues concerning patient management are also discussed.

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