Leber’s Hereditary Optic Neuropathy Associated With Schizophrenia

Laurent Boyer, MD, PhD; Eric Guedj, MD, PhD; Daniel Dassa, MD, PhD; and Christophe Lancon, MD, PhD

Published: September 15, 2012

Article Abstract

Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.

Leber’s hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease characterized by bilateral visual loss of central vision, generally affecting young men. Three main mutations of mitochondrial DNA (mtDNA) involved in complex I of the oxidative phosphorylation system have been reported, encompassing over 90% of patients: G3460A (genetic subunit ND1), G11778A (ND4), and T14484C (ND6). Mitochondrial oxidative phosphorylation is the major pathway producing adenosine triphosphatase (ATP), which supplies more than 95% of the total energy requirements in cells.

Volume: 73

Quick Links: Schizophrenia and Schizoaffective Disorders

Continue Reading…

Subscribe to read the entire article


Buy this Article as a PDF


Sign-up to stay
up-to-date today!


Already registered? Sign In

Original Research

Sublingual Dexmedetomidine for the Treatment of Acute Agitation in Adults With Schizophrenia or Schizoaffective Disorder: A Randomized Placebo-Controlled Trial

This RCT determined whether a single dose of sublingual dexmedetomidine reduced acute agitation associated with schizophrenia or...