Leber’s Hereditary Optic Neuropathy Associated With Schizophrenia

Article Abstract

Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.

Leber’s hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease characterized by bilateral visual loss of central vision, generally affecting young men. Three main mutations of mitochondrial DNA (mtDNA) involved in complex I of the oxidative phosphorylation system have been reported, encompassing over 90% of patients: G3460A (genetic subunit ND1), G11778A (ND4), and T14484C (ND6). Mitochondrial oxidative phosphorylation is the major pathway producing adenosine triphosphatase (ATP), which supplies more than 95% of the total energy requirements in cells.

Volume: 73

Quick Links: Schizophrenia and Schizoaffective Disorders

Continue Reading…

Subscribe to read the entire article


Buy this Article as a PDF


Sign-up to stay
up-to-date today!


Already registered? Sign In

Original Research

Recovering From Intimate Partner Violence Through Strengths and Empowerment: Findings From a Randomized Clinical Trial

This RCT focused on a psychosocial counseling intervention for women experiencing intimate partner violence (IPV). Outcomes such...