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Serotonin-1D Hypothesis of Obsessive-Compulsive Disorder: An Update

Joseph Zohar, MD; James L. Kennedy, MD; Eric Hollander, MD; and Lorrin M. Koran, MD

Published: December 15, 2004

Article Abstract

Support for the serotonin-1D (5-HT1D) hypothesis of obsessive-compulsive disorder (OCD) andrelated conditions comes from a variety of sources. Some pharmacologic challenges with the 5-HT1D agonistsumatriptan, and case reports in which prolonged administration of 5-HT1D agonists was associatedwith a therapeutic effect, suggest that 5-HT1D may play a role in obsessive-compulsive symptoms. Geneticstudies have also found that polymorphism of the 5-HT1D gene may be preferentially transmittedto those patients with OCD. However, taking into account that OCD is a heterogeneous syndrome, the5-HT1D hypothesis requires further investigation in order to disentangle the role of the 5-HT1D receptor inthis common and often severe disorder.

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