This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Articles

Antidepressant Treatment of Posttraumatic Stress Disorder

Teri Pearlstein, MD

Published: April 30, 2000

Article Abstract

Recent large double-blind, placebo-controlled trials have indicated that sertraline is an effective andwell-tolerated treatment for posttraumatic stress disorder (PTSD). The avoidance/numbing symptomcluster improved the most significantly with sertraline, but significant improvements were also notedfor the intrusive/reexperiencing and arousal symptom clusters. Smaller double-blind, placebo-controlledtrials have also indicated that fluoxetine is an effective treatment for PTSD. Multiple small, open studieswith other selective serotonin reuptake inhibitors and newer antidepressants indicate that these medicationsshow some promise. Older studies indicate some efficacy for tricyclic antidepressants, and monoamineoxidase inhibitors are a reasonable choice, particularly for intrusive/reexperiencing symptoms.


Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 61

Quick Links: PTSD , Trauma

Sign-up to stay
up-to-date today!

SUBSCRIBE

Already registered? Sign In

Original Research

Frontothalamic Circuit Abnormalities in Patients With Bipolar Depression and Suicide Attempts

To identify potential markers for suicide risk, this fMRI study looked at neural activity in bipolar depression...

Read More...