April 6, 2021
Persons With Debt Burden Are More Likely to Report Suicide Attempt Than Those Without: A National Study of US Adults
Suicide rates are increasing, but understanding of its predictors is incomplete, especially regarding self-perceived financial well-being. This study assessed the association between debt burden and self-reported suicide attempt among US adults.
The COVID-19 pandemic has affected the daily life of millions worldwide, with still unclear effects on mental health. This study examined patterns in pediatric psychiatric visits to hospital emergency departments in Italy during the pandemic lockdown.
March 30, 2021
Active Placebo, the Parachute Meta-Analysis, the Nobel Prize, and the Efficacy of Electroconvulsive Therapy
Electroconvulsive therapy has a negative connotation in many circles, but is it getting a bad rap? Dr Andrade offers thoughtful counterpoints to the criticism.
In this letter, Dr Henandez and colleagues reply to a letter from Brigido et al that comments on their recent article on the impact of comorbid posttraumatic stress disorder on outcomes of treatment with repetitive transcranial magnetic stimulation in depressed veterans.
Screening Tests Are Not Diagnostic: A Commentary on a Study of Electroconvulsive Therapy for Depressed Patients With and Without Borderline Personality Disorder
This commentary discusses a recent article on the use of electroconvulsive therapy for depressed patients with and without borderline personality disorder.
Posttraumatic Stress Disorder Symptom Severity Does Not Predict Depression Improvement, but May Impact Clinical Response and Remission
This letter to the editor builds on the findings of a recent article by Hernandez and colleagues on the impact of comorbid posttraumatic stress disorder on outcomes of treatment with repetitive transcranial magnetic stimulation in depressed veterans.
Both frailty and late-life depression are associated with higher mortality rates. This study explored the association of physical frailty with mortality in depressed older patients.
March 23, 2021
Can a patient-centered approach to treatment be adopted for patients with schizophrenia? Can these patients take part in shared decision-making? Follow along as Dr Harvey shares his expertise.
Patients may be more willing to accept some adverse effects than others. Dr Kane offers advice on addressing side effects that prevent patients from maintaining their medication adherence.
Could prazosin help patients with alcohol use disorder who experience intense withdrawal symptoms? Dr Andrade considers the evidence and the findings of a recent large RCT.
Insomnia, Suicidal Ideation, and Suicide Attempts in the Clinical Antipsychotic Trials of Intervention Effectiveness
Insomnia is common in schizophrenia, but how does it affect suicidality and symptoms in these patients? This analysis of CATIE data provides answers.
Are women who have postpartum psychiatric episodes more likely to get a divorce than women who do not experience such episodes? Read this report of a population-based cohort study to learn more.
High Prevalence and Incidence of Obsessive-Compulsive Disorder Among Women Across Pregnancy and the Postpartum
When screening for perinatal OCD, do you ask infant-specific questions? If not, patients may not make the connection to their symptoms. Learn more in this journal CME article.
March 16, 2021
Insomnia is often comorbid with psychiatric, medical, and neurologic disorders. Follow along as Dr Rosenberg discusses the bidirectional relationship between insomnia disorder and frequently co-occurring conditions.
The link between suicidality and interpersonal difficulties extends the traditional approach of comprehending suicide as mainly related to depression. This study of adult outpatients investigated the link between separation anxiety disorder and suicidality.
To diagnose insomnia disorder, how do you conduct an effective interview with patients? What assessment tools do you use? Review the evaluation process with an expert.
Telehealth Treatment of Patients in an Intensive Acute Care Psychiatric Setting During the COVID-19 Pandemic: Comparative Safety and Effectiveness to In-Person Treatment
Because of COVID-19, much behavioral health care is now delivered virtually. Is this as effective as in-person treatment? Read the article to learn more.
The Prevalence and National Burden of Treatment-Resistant Depression and Major Depressive Disorder in the United States
How prevalent is treatment-resistant depression (TRD), and what proportion of the burden of medication-treated major depressive disorder is accounted for by TRD? This study explores those questions using the most commonly accepted definition of TRD.
March 9, 2021
How to Evaluate Patients and Educate Them About Self-Examinations for Tardive Dyskinesia Between Appointments
In brief videos, Drs McEvoy and Nierenberg discuss symptoms of tardive dyskinesia, how to observe patients (whether in person or via telemedicine), and how to educate patients and families about TD.
Increased Prevalence of Subclinical Hypothyroidism and Thyroid Autoimmunity in Depressed Adolescents: Results From a Clinical Cross-Sectional Study in Comparison to the General Pediatric Population
Could hypothyroidism and thyroid autoimmunity be linked to depression in adolescents? Read this clinical study of 360 youth with depression and find out.
March 3, 2021
Changes in Diagnostic and Demographic Characteristics of Patients Seeking Mental Health Care During the Early COVID-19 Pandemic in a Large, Community-Based Health Care System
This study sought to identify patients vulnerable to worsening mental health during the early COVID-19 pandemic. Read this article to learn about the dramatic changes in psychiatric care experienced by these patients.
February 23, 2021
This letter points to the disparity in resources devoted to combating COVID-19 versus another preventable epidemic: suicide.
Shorter- and Longer-Term Risk for Suicide Among Male US Military Veterans in the Year After Discharge From Psychiatric Hospitalization
Does suicide risk shortly after discharge from psychiatric hospitalization differ from risk thereafter? This study compared risk factors for suicide in US veterans in the first 90 days after discharge to those during the remainder of the year.
Treatment Effect With Paliperidone Palmitate Compared With Oral Antipsychotics in Black/African American Patients With Schizophrenia and a History of Criminal Justice System Involvement: A Post Hoc Analysis of the PRIDE Study
This study examined the use of injectable paliperidone palmitate in Black/African American patients with schizophrenia and prior criminal justice system involvement. Read it to see if treatment failures were reduced with paliperidone vs oral medications.
Convolutional Neural Network–Based Deep Learning Model for Predicting Differential Suicidality in Depressive Patients Using Brain Generalized q-Sampling Imaging
Even given known risk factors for suicide, predicting suicide is difficult. This study used deep learning of structural magnetic resonance imaging to create an algorithm for detecting suicidal ideation and suicidal attempts.
Therapeutic Potential of Psychedelics in the Treatment of Psychiatric Disorders, Part 1: Psychopharmacology and Neurobiological Effects
In addition to altering one’s perception of reality, psychedelics may be useful for treating certain psychiatric disorders. This brief review looks at the mechanisms behind their effects.
Incidents involving both a homicide and a suicide are rare and vary widely in terms of motive and circumstances. Read this study to learn about 8 classifications of homicide-suicides the authors developed using a large database.
Levels of several fatty acids (FAs) have been linked to suicidal behavior, though research has mainly focused on individual FAs. This study used latent class cluster analysis to identify groupings of FAs that may affect likelihood of suicidal behavior.
Pharmacotherapy for Attention-Deficit/Hyperactivity Disorder and Retention in Outpatient Substance Use Disorder Treatment: A Retrospective Cohort Study
How does comorbid attention-deficit/hyperactivity disorder (ADHD) affect individuals with substance use disorder (SUD)? Is treatment for ADHD associated with retention in outpatient SUD therapy?
Therapeutic Potential of Psychedelics in Treatment of Psychiatric Disorders, Part 2: Review of the Evidence
Could psychedelics such as psilocybin and LSD be useful in treating MDD or other psychiatric disorders? This brief review looks at the evidence.
Electroconvulsive therapy (ECT) use in children and adolescents is much less common than in adults, and the evidence base for its use in youth is limited. This study reports outcomes of a cohort of youth treated with ECT at an academic medical center.
February 18, 2021
Risk Factors for Reattempt and Suicide Within 6 Months After an Attempt in the French ALGOS Cohort: A Survival Tree Analysis
Understanding risk factors for suicidal behavior is crucial for the development of effective prevention plans. Do anxiety disorders or alcohol use disorder play a role? Learn more in this CME activity.
Two recent meta-analyses found little effect of N-acetylcysteine augmentation in MDD or bipolar depression, although some past research has indicated its efficacy. In this article, Dr Andrade takes a closer look at whether the evidence supports its use.
HARKing, Cherry-Picking, P-Hacking, Fishing Expeditions, and Data Dredging and Mining as Questionable Research Practices
In this article, Dr Andrade helps readers identify several types of statistical analysis that violate scientific principles and that researchers may knowingly—or unknowingly—engage in.
January 19, 2021
Treatment Outcomes of Electroconvulsive Therapy for Depressed Patients With and Without Borderline Personality Disorder: A Retrospective Cohort Study
Borderline personality disorder (BPD) is thought to lead to poor response to electroconvulsive therapy (ECT) in depressed patients. This study assessed symptom-severity outcomes among depressed patients with and without comorbid BPD who received ECT.
Building Resilience Among Frontline Health Care Workers: Strategies to Consider for Implementing Evidence-Based Practices
This commentary discusses a recent brief report by Pietrzak et al and lists 3 strategies that health care systems could use to improve mental health support for frontline health care workers during the COVID-19 pandemic.
Predictors of Suicidal Ideation and Preparatory Behaviors in Individuals With Bipolar Disorder: The Contribution of Chronobiological Dysrhythmicity and Its Association With Hopelessness
Evidence has shown that bipolar disorder is often linked to alterations in circadian rhythms. This study looked at the impact of these rhythms on suicide risk, as well as the role of hopelessness, in patients with bipolar disorder.
The question of whether, and when, antidepressants are appropriate in bipolar disorder is a hotly debated topic. This ASCP Corner article summarizes the key concepts with greatest relevance for clinical decision-making.
January 12, 2021