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JCP Weekly
February 16, 2021
Risk Factors for Reattempt and Suicide Within 6 Months After an Attempt in the French ALGOS Cohort: A Survival Tree Analysis
Understanding risk factors for suicidal behavior is crucial for the development of effective prevention plans. Do anxiety disorders or alcohol use disorder play a role? Learn more in this CME activity.
N-Acetylcysteine Augmentation for Patients With Major Depressive Disorder and Bipolar Depression
Two recent meta-analyses found little effect of N-acetylcysteine augmentation in MDD or bipolar depression, although some past research has indicated its efficacy. In this article, Dr Andrade takes a closer look at whether the evidence supports its use.
HARKing, Cherry-Picking, P-Hacking, Fishing Expeditions, and Data Dredging and Mining as Questionable Research Practices
In this article, Dr Andrade helps readers identify several types of statistical analysis that violate scientific principles and that researchers may knowingly—or unknowingly—engage in.
January 12, 2021
How Much Is the Debate Over Antidepressant Efficacy and Safety in Bipolar Depression an Artifact of Study Methodologies?
This editorial discusses a recent study of citalopram in bipolar depression and revisits the long-held assumption that antidepressants lead to poor outcomes in bipolar disorder.
Dr Andrade Replies
Here, Dr Andrade replies to a letter to the editor regarding a recent Clinical and Practical Psychopharmacology column on use of baclofen in alcohol use disorder patients.
Effects of Long-Acting Injectable Paliperidone Palmitate on Clinical and Functional Outcomes in Patients With Schizophrenia Based on Illness Duration
Although long-acting injectable (LAI) antipsychotics show benefit in the early stages of schizophrenia, they are mostly used later in the illness. This study assessed clinical and functional improvement with paliperidone LAI at different illness durations.
Citalopram for Acute and Preventive Efficacy in Bipolar Depression (CAPE-BD): A Randomized, Double-Blind, Placebo-Controlled Trial
Antidepressants are widely used to treat bipolar illness, though their effectiveness in this disorder has not been established. This randomized, double-blind, placebo-controlled trial assessed the efficacy and safety of citalopram in bipolar depression.
Optimal Long-Acting Injectable Antipsychotic Management During COVID-19
Long-acting injectable antipsychotics are effective for preventing relapse in schizophrenia, but in-person administration of them is a challenge during a pandemic. This report describes how a clinic successfully reduced in-person injections by 40%.
January 05, 2021
How Much Is the Debate Over Antidepressant Efficacy and Safety in Bipolar Depression an Artifact of Study Methodologies?
This editorial discusses a recent study of citalopram in bipolar depression and revisits the long-held assumption that antidepressants lead to poor outcomes in bipolar disorder.
Dr Andrade Replies
Here, Dr Andrade replies to a letter to the editor regarding a recent Clinical and Practical Psychopharmacology column on use of baclofen in alcohol use disorder patients.
Effects of Long-Acting Injectable Paliperidone Palmitate on Clinical and Functional Outcomes in Patients With Schizophrenia Based on Illness Duration
Although long-acting injectable (LAI) antipsychotics show benefit in the early stages of schizophrenia, they are mostly used later in the illness. This study assessed clinical and functional improvement with paliperidone LAI at different illness durations.
Citalopram for Acute and Preventive Efficacy in Bipolar Depression (CAPE-BD): A Randomized, Double-Blind, Placebo-Controlled Trial
Antidepressants are widely used to treat bipolar illness, though their effectiveness in this disorder has not been established. This randomized, double-blind, placebo-controlled trial assessed the efficacy and safety of citalopram in bipolar depression.
Optimal Long-Acting Injectable Antipsychotic Management During COVID-19
Long-acting injectable antipsychotics are effective for preventing relapse in schizophrenia, but in-person administration of them is a challenge during a pandemic. This report describes how a clinic successfully reduced in-person injections by 40%.
December 29, 2020
Associations Between ADHD Medication Use in Pregnancy and Severe Malformations Based on Prenatal and Postnatal Diagnoses: A Danish Registry-Based Study
Do you have patients who take ADHD medication and are planning a pregnancy? How do you respond to questions of safety? This journal CME activity offers evidence.
Sociodemographic Factors, Health Behaviors, and Biological Indicators Associated With Suicide Mortality Among Young Adults in South Korea: A Nationwide Cohort Study Among 15 Million Men and Women
Sociodemographic factors, health behaviors, and biological indicators as risks for suicide are relatively understudied among young adults. This study sought to determine which nonpsychiatric factors might be associated with suicide among young people.
Psychological Resilience in Frontline Health Care Workers During the Acute Phase of the COVID-19 Pandemic in New York City
Read this brief report examining stressors as well as factors associated with resilience among New York City health care workers in the acute phase of the COVID-19 pandemic.
December 22, 2020
Sociodemographic Factors, Health Behaviors, and Biological Indicators Associated With Suicide Mortality Among Young Adults in South Korea: A Nationwide Cohort Study Among 15 Million Men and Women
Sociodemographic factors, health behaviors, and biological indicators as risks for suicide are relatively understudied among young adults. This study sought to determine which nonpsychiatric factors might be associated with suicide among young people.
Psychological Resilience in Frontline Health Care Workers During the Acute Phase of the COVID-19 Pandemic in New York City
Read this brief report examining stressors as well as factors associated with resilience among New York City health care workers in the acute phase of the COVID-19 pandemic.
Prevalence and Correlates of Caregiver-Reported Mental Health Conditions in Youth With Autism Spectrum Disorder in the United States
People with autism spectrum disorder (ASD) experience health conditions at above-average rates, but how are they affected by concurrent mental disorders? This analysis of survey data looks at the prevalence of specific conditions such as ADHD and anxiety.
Common and Country-Specific Characteristics Associated With Suicidality in the Arab Region
Research on suicidality in the Arab region is scarce. This study explored recent and present suicidality as well as demographic characteristics associated with such attempts among residents in this region looking for depression information online.
December 15, 2020
Prevalence and Correlates of Caregiver-Reported Mental Health Conditions in Youth With Autism Spectrum Disorder in the United States
People with autism spectrum disorder (ASD) experience health conditions at above-average rates, but how are they affected by concurrent mental disorders? This analysis of survey data looks at the prevalence of specific conditions such as ADHD and anxiety.
Common and Country-Specific Characteristics Associated With Suicidality in the Arab Region
Research on suicidality in the Arab region is scarce. This study explored recent and present suicidality as well as demographic characteristics associated with such attempts among residents in this region looking for depression information online.
Efficacy and Safety of HP-3070, an Asenapine Transdermal System, in Patients With Schizophrenia: A Phase 3, Randomized, Placebo-Controlled Study
Transdermal asenapine administration may address unmet needs in patients with schizophrenia, including improved adherence. This phase 3 study assessed efficacy and safety of HP-3070, an asenapine transdermal system (patch), in adults with schizophrenia.
Toward Targeted ECT: The Interdependence of Predictors of Treatment Response in Depression Further Explained
Several clinical variables assumed to predict electroconvulsive therapy (ECT) outcome in major depressive disorder are interrelated. This study tries to disentangle this interdependence to distill the most important predictors of ECT treatment success.
December 08, 2020
Efficacy and Safety of HP-3070, an Asenapine Transdermal System, in Patients With Schizophrenia: A Phase 3, Randomized, Placebo-Controlled Study
Transdermal asenapine administration may address unmet needs in patients with schizophrenia, including improved adherence. This phase 3 study assessed efficacy and safety of HP-3070, an asenapine transdermal system (patch), in adults with schizophrenia.
Toward Targeted ECT: The Interdependence of Predictors of Treatment Response in Depression Further Explained
Several clinical variables assumed to predict electroconvulsive therapy (ECT) outcome in major depressive disorder are interrelated. This study tries to disentangle this interdependence to distill the most important predictors of ECT treatment success.
Antipsychotic Medication Prescriptions for Homeless and Unstably Housed Veterans in the Veterans Affairs Health Care System
Many homeless and unstably housed (HUH) adults have severe mental illness managed with antipsychotic medications. This study examined antipsychotic medication use and correlates of antipsychotic medication prescriptions among HUH versus non-HUH veterans.
Dr Uher and Colleagues Reply
In this letter to the editor, Dr Uher and colleagues reply to Drs Swami and Mishra.
Interest-Activity Dimension and Response to Aripiprazole
This letter comments on methodologic aspects of a recent study by Uher and colleagues.
December 01, 2020
Antipsychotic Medication Prescriptions for Homeless and Unstably Housed Veterans in the Veterans Affairs Health Care System
Many homeless and unstably housed (HUH) adults have severe mental illness managed with antipsychotic medications. This study examined antipsychotic medication use and correlates of antipsychotic medication prescriptions among HUH versus non-HUH veterans.
Dr Uher and Colleagues Reply
In this letter to the editor, Dr Uher and colleagues reply to Drs Swami and Mishra.
Interest-Activity Dimension and Response to Aripiprazole
This letter comments on methodologic aspects of a recent study by Uher and colleagues.
Is COVID-19 Associated With Posttraumatic Stress Disorder?
Because COVID-19 is associated with a risk of death and lack of effective treatments, patients are at risk of developing PTSD. This cohort study assessed the prevalence of PTSD in outpatients, hospitalized patients, and those requiring an ICU stay.
Effect of Adjunctive Pimavanserin on Sleep/Wakefulness in Patients With Major Depressive Disorder: Secondary Analysis From CLARITY
Adjunctive pimavanserin can reduce depressive symptoms and improve function in patients with major depression and inadequate antidepressant response. This analysis evaluated the effects of adjunctive pimavanserin on sleep/wakefulness disturbances.
November 24, 2020
Effect of Adjunctive Pimavanserin on Sleep/Wakefulness in Patients With Major Depressive Disorder: Secondary Analysis From CLARITY
Adjunctive pimavanserin can reduce depressive symptoms and improve function in patients with major depression and inadequate antidepressant response. This analysis evaluated the effects of adjunctive pimavanserin on sleep/wakefulness disturbances.
Paternal Depression as a Risk Factor for Neurodevelopmental Disorders in Offspring: Implications for Maternal Depression and Its Treatment During Pregnancy
Gestational exposure to antidepressants has been associated with risk of autism and ADHD, and a recent study also showed maternal depression as a risk factor. Intriguingly, paternal depression was also a risk factor. Dr Andrade explores the implications.
Sexual Orientation, Adverse Childhood Experiences, and Comorbid DSM-5 Substance Use and Mental Health Disorders
People in sexual minority groups are more likely than heterosexual individuals to experience adverse childhood experiences. Is trauma in childhood associated with increased mental health and substance use disorders in adulthood? Find survey data here.
Pharmacology and Evidence-Based Strategies for Current and Emerging Treatments for OFF Periods in Parkinson Disease
After several years, patients with Parkinson disease often experience OFF episodes, or periods each day when medication efficacy "wears off." How can you increase their ON time? In this CME activity, follow along as 2 experts review evidence on treatment.
Diagnosing Dementia-Related Psychosis: Using Tools and Communicating With Patients and Caregivers
What diagnostic criteria and assessment tools would you use for dementia-related psychosis? What strategies may help when discussing psychosis with patients' family members? Dr Ballard considers these topics in this brief CME activity.
November 17, 2020
Gabapentin for Alcohol-Related Disorders: Critical Appraisal of the Symptom-Driven Approach
This article examines a role for gabapentin in reducing alcohol consumption in a specific subpopulation of alcohol use disorder patients: those with high alcohol intake and high levels of withdrawal symptoms.
Long-Acting Injectable Antipsychotic Use During Pregnancy: A Brief Review and Concise Guide for Clinicians
Women with psychotic and mood disorders are at greater risk of symptoms during pregnancy, but some clinicians avoid use of LAIs in these patients due to safety concerns. This article highlights points to consider in the decision-making process.
Outcomes of Neuroleptic Malignant Syndrome With Depot Versus Oral Antipsychotics: A Systematic Review and Pooled, Patient-Level Analysis of 662 Case Reports
Is the advantage of longer-term medication release with long-acting injectable antipsychotics offset by an increased risk of more prolonged and severe neuroleptic malignant syndrome? This systematic review and pooled analysis address that question.
Recognizing and Treating Excessive Daytime Sleepiness in Patients With Narcolepsy
Sleep experts Drs Roth and Winkelman explore the differential diagnosis and treatment of narcolepsy in this CME journal activity.
An Association Between the Inflammatory Biomarker GlycA and Depressive Symptom Severity
Since the association of the inflammatory biomarker hs-CRP with depression is unclear, alternative inflammatory biomarkers of depression are needed. This study examined the association between the inflammatory biomarker GlycA and depressive symptoms.
