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JCP Weekly
June 8, 2021
Fluoxetine for Stroke: A Mixed Bag of Outcomes
Dr Andrade discusses the findings of a meta-analysis and two recent RCTs that indicate fluoxetine may not be a good choice in patients recovering from stroke.
Investigational Treatment of Depressive Disorders With Neuroactive Steroids: Potential Implications for Premenstrual Dysphoric Disorder
Recent promising data indicate that neuroactive steroids could have a role in treating depression. This article discusses the mechanisms behind potential beneficial effects in premenstrual dysphoric disorder as well.
June 1, 2021
Lemborexant for the Treatment of Insomnia: Direct and Indirect Comparisons With Other Hypnotics Using Number Needed to Treat, Number Needed to Harm, and Likelihood to Be Helped or Harmed
Many pharmacologic treatment options are available for insomnia. In this study, the clinical utility of the new hypnotic lemborexant is given clinical perspective via the evidence-based medicine tools of number needed to treat and number needed to harm.
β-Blockers and the Risk of New-Onset Depression: Meta-analysis Reassures, but the Jury Is Still Out
β-Blocker treatment has long been associated with depression, but is there more to the story than meets the eye? Dr Andrade considers the findings of a recent large meta-analysis—and why the question remains to be settled.
A Systematic Review of Complex Polypharmacy in Bipolar Disorder: Prevalence, Clinical Features, Adherence, and Preliminary Recommendations for Practitioners
Complex pharmacotherapy is common in patients with bipolar disorder. This study examined the prevalence of such complex regimens in bipolar disorder patients and sought to characterize factors that influence polypharmacy prescribing patterns.
May 25, 2021
Can Emerging Therapies Resolve Unmet Needs With Current Treatment in Early-stage Alzheimer Disease?
How do investigational drugs for Alzheimer disease differ from those currently prescribed to patients? Dr Burke shares her insights.
Meta-Analysis of the Treatment of Posttraumatic Stress Disorder in Adults With Comorbid Severe Mental Illness
For patients who have PTSD and also have a severe mental illness, can psychotherapies for PTSD still be effective? If so, what component might offer greater efficacy?
May 18, 2021
The Importance of Context in Identifying the Recovery Needs of Women With Psychosis
This commentary discusses the article by Dubreucq and colleagues that examined objective and subjective aspects of recovery among clinically stable outpatients with schizophrenia spectrum disorders.
Sex Differences in Recovery-Related Outcomes and Needs for Psychiatric Rehabilitation in People With Schizophrenia Spectrum Disorder
Female gender has been associated with better outcomes in schizophrenia spectrum disorders (SSDs). This study investigated gender differences in recovery-related outcomes and psychiatric rehabilitation needs in a multicenter sample of patients with SSD.
May 11, 2021
Talking with Patients and Care Partners About Treatment Goals and Challenges in Early-Stage Alzheimer Disease
In this webcast about early-stage Alzheimer disease, Drs Burke and Apostolova highlight important conversations to have with patients and their care partners on topics such as diet, exercise, driving, and plans for the later stage of illness.
A Change in Blood Carbamazepine Levels Associated With Cannabis Use: Implications for Clinical Practice
This report describes carbamazepine level fluctuations that occurred concurrent with stopping and restarting of cannabis use in a patient with bipolar disorder.
Obsessive-Compulsive Disorder and Dementia Risk: A Nationwide Longitudinal Study
Case reports suggest a link between obsessive-compulsive disorder (OCD) and dementia, but this association has received little research. The current study investigated dementia risk among OCD patients using a national health insurance research database.
Therapeutic Response Is Associated With Antipsychotic-Induced Weight Gain in Drug-Naive First-Episode Patients With Schizophrenia: An 8-Week Prospective Study
How does weight gain during antipsychotic treatment relate to therapeutic response? This 8-week study investigates the question.
Advances in Diagnosis of Alzheimer Disease and Emerging Treatment Targets
Great strides in research on Alzheimer disease diagnostic biomarkers and treatment targets have taken place over the past 2 decades. Listen as Dr Goldfarb highlights exciting developments.
May 4, 2021
Early-Stage Alzheimer Primer: Pathophysiology, Diagnosis, and Assessment
What are the steps for diagnosing Alzheimer disease? Are you familiar with diagnostic criteria and assessment tools? In this webcast, walk through the process with an expert.
Addressing Patients’ Unmet Needs to Improve Outcomes in Schizophrenia
What are some of the challenges you face in overcoming adherence issues and providing patient-centered care for people living with schizophrenia? Drs Harvey and Kane offer evidence and clinical experience on these topics in this journal CME activity.
Trends in Medication Prescribing in Patients With PTSD From 2009 to 2018: A National Veterans Administration Study
Although psychotherapy is available via the Veterans Health Administration, most veterans diagnosed with posttraumatic stress disorder (PTSD) receive pharmacotherapy. This study evaluated longitudinal prescription practice trends for veterans with PTSD.
Marine Omega-3 Fatty Acid Supplementation for Borderline Personality Disorder: A Meta-Analysis
This comprehensive meta-analysis informs clinicians and patients about the potential effectiveness of omega-3 fatty acids as add-on therapy for borderline personality disorder.
April 27, 2021
Studies Support the Use of Suvorexant for the Prevention of Delirium
Izuhara and colleagues reply to a letter commenting on their recent article.
Transdiagnostic Psychiatric Symptoms, Burnout, and Functioning in Frontline Health Care Workers Responding to the COVID-19 Pandemic: A Symptomics Analysis
The pandemic has clearly placed a tremendous strain on health care workers, but how has it affected their ability to function in their daily lives and the likelihood of burnout? This large survey from a New York hospital provides some answers.
Evidence-Based Treatment and Monitoring Strategies for Dementia-Related Psychosis
Antipsychotics can be used in the short term to manage dementia-related psychosis, but serious adverse effects can outweigh benefits. Novel antipsychotics or other agents may offer superior efficacy and safety. Explore the evidence in this CME activity.
It Is Too Early to Put Delirium Prophylaxis to Bed: Stronger Evidence Is Needed for Suvorexant
This letter comments on a recent JCP article by Izuhara et al.
April 20, 2021
The Epigenetic Connection to Black Disparity
Dr Post discusses the epigenetic marks left by environmental stressors and deprivation and their consequences for the physical and mental health of blacks in the US.
Posttraumatic Distress Symptoms and Their Response to Treatment in Adults With Prolonged Grief Disorder
Posttraumatic stress disorder and prolonged grief disorder (PGD) both arise following major life stressors. This study examined the presence and response to treatment of posttraumatic stress symptoms in bereaved adults with a primary diagnosis of PGD.
April 13, 2021
Cross-Sectional Associations Among Symptoms of Pain, Irritability, and Depression and How These Symptoms Relate to Social Functioning and Quality of Life: Findings From the EMBARC and STRIDE Studies and the VitalSign6 Project
Is pain associated with irritability and depression? This study aimed to evaluate relationships between these symptom categories and determine how they may relate to functional impairments.
Antipsychotic Use and Bloodstream Infections Among Adult Patients With Chronic Obstructive Pulmonary Disease: A Cohort Study
Antipsychotics may have immunomodulatory effects that could increase the risk of disseminated infections. This study sought to estimate the effect of antipsychotics on incident bloodstream infections in adults with chronic obstructive pulmonary disease.
April 6, 2021
