MY ACCOUNT
JCP Weekly
April 6, 2021
Persons With Debt Burden Are More Likely to Report Suicide Attempt Than Those Without: A National Study of US Adults
Suicide rates are increasing, but understanding of its predictors is incomplete, especially regarding self-perceived financial well-being. This study assessed the association between debt burden and self-reported suicide attempt among US adults.
Impact of the COVID-19 Pandemic on Child and Adolescent Psychiatric Emergencies
The COVID-19 pandemic has affected the daily life of millions worldwide, with still unclear effects on mental health. This study examined patterns in pediatric psychiatric visits to hospital emergency departments in Italy during the pandemic lockdown.
March 30, 2021
Active Placebo, the Parachute Meta-Analysis, the Nobel Prize, and the Efficacy of Electroconvulsive Therapy
Electroconvulsive therapy has a negative connotation in many circles, but is it getting a bad rap? Dr Andrade offers thoughtful counterpoints to the criticism.
Veterans With Comorbid Depression and PTSD Can Be Effectively Treated With TMS
In this letter, Dr Henandez and colleagues reply to a letter from Brigido et al that comments on their recent article on the impact of comorbid posttraumatic stress disorder on outcomes of treatment with repetitive transcranial magnetic stimulation in depressed veterans.
Screening Tests Are Not Diagnostic: A Commentary on a Study of Electroconvulsive Therapy for Depressed Patients With and Without Borderline Personality Disorder
This commentary discusses a recent article on the use of electroconvulsive therapy for depressed patients with and without borderline personality disorder.
Posttraumatic Stress Disorder Symptom Severity Does Not Predict Depression Improvement, but May Impact Clinical Response and Remission
This letter to the editor builds on the findings of a recent article by Hernandez and colleagues on the impact of comorbid posttraumatic stress disorder on outcomes of treatment with repetitive transcranial magnetic stimulation in depressed veterans.
Frailty as a Predictor of Mortality in Late-Life Depression: A Prospective Clinical Cohort Study
Both frailty and late-life depression are associated with higher mortality rates. This study explored the association of physical frailty with mortality in depressed older patients.
March 23, 2021
Patient-Centered Treatment Strategies to Improve Outcomes in Schizophrenia
Can a patient-centered approach to treatment be adopted for patients with schizophrenia? Can these patients take part in shared decision-making? Follow along as Dr Harvey shares his expertise.
Lessening the Side Effect Burden to Improve Adherence Among Individuals With Schizophrenia
Patients may be more willing to accept some adverse effects than others. Dr Kane offers advice on addressing side effects that prevent patients from maintaining their medication adherence.
Prazosin for Alcohol Use Disorder: A Symptom-Driven Approach to the Choice of Intervention
Could prazosin help patients with alcohol use disorder who experience intense withdrawal symptoms? Dr Andrade considers the evidence and the findings of a recent large RCT.
Insomnia, Suicidal Ideation, and Suicide Attempts in the Clinical Antipsychotic Trials of Intervention Effectiveness
Insomnia is common in schizophrenia, but how does it affect suicidality and symptoms in these patients? This analysis of CATIE data provides answers.
Divorce or Separation Following Postpartum Psychiatric Episodes: A Population-Based Cohort Study
Are women who have postpartum psychiatric episodes more likely to get a divorce than women who do not experience such episodes? Read this report of a population-based cohort study to learn more.
High Prevalence and Incidence of Obsessive-Compulsive Disorder Among Women Across Pregnancy and the Postpartum
When screening for perinatal OCD, do you ask infant-specific questions? If not, patients may not make the connection to their symptoms. Learn more in this journal CME article.
March 16, 2021
The Bidirectional Relationship Between Insomnia and Comorbid Disorders
Insomnia is often comorbid with psychiatric, medical, and neurologic disorders. Follow along as Dr Rosenberg discusses the bidirectional relationship between insomnia disorder and frequently co-occurring conditions.
Separation Anxiety and Measures of Suicide Risk Among Patients With Mood and Anxiety Disorders
The link between suicidality and interpersonal difficulties extends the traditional approach of comprehending suicide as mainly related to depression. This study of adult outpatients investigated the link between separation anxiety disorder and suicidality.
Prevalence, Impact, and Burden of Insomnia and Discussing It With Patients
To diagnose insomnia disorder, how do you conduct an effective interview with patients? What assessment tools do you use? Review the evaluation process with an expert.
Telehealth Treatment of Patients in an Intensive Acute Care Psychiatric Setting During the COVID-19 Pandemic: Comparative Safety and Effectiveness to In-Person Treatment
Because of COVID-19, much behavioral health care is now delivered virtually. Is this as effective as in-person treatment? Read the article to learn more.
The Prevalence and National Burden of Treatment-Resistant Depression and Major Depressive Disorder in the United States
How prevalent is treatment-resistant depression (TRD), and what proportion of the burden of medication-treated major depressive disorder is accounted for by TRD? This study explores those questions using the most commonly accepted definition of TRD.
March 9, 2021
How to Evaluate Patients and Educate Them About Self-Examinations for Tardive Dyskinesia Between Appointments
In brief videos, Drs McEvoy and Nierenberg discuss symptoms of tardive dyskinesia, how to observe patients (whether in person or via telemedicine), and how to educate patients and families about TD.
Increased Prevalence of Subclinical Hypothyroidism and Thyroid Autoimmunity in Depressed Adolescents: Results From a Clinical Cross-Sectional Study in Comparison to the General Pediatric Population
Could hypothyroidism and thyroid autoimmunity be linked to depression in adolescents? Read this clinical study of 360 youth with depression and find out.
March 3, 2021
Changes in Diagnostic and Demographic Characteristics of Patients Seeking Mental Health Care During the Early COVID-19 Pandemic in a Large, Community-Based Health Care System
This study sought to identify patients vulnerable to worsening mental health during the early COVID-19 pandemic. Read this article to learn about the dramatic changes in psychiatric care experienced by these patients.
February 23, 2021
If Suicide Were COVID-19: A Neglected Cause of Premature Death
This letter points to the disparity in resources devoted to combating COVID-19 versus another preventable epidemic: suicide.
Shorter- and Longer-Term Risk for Suicide Among Male US Military Veterans in the Year After Discharge From Psychiatric Hospitalization
Does suicide risk shortly after discharge from psychiatric hospitalization differ from risk thereafter? This study compared risk factors for suicide in US veterans in the first 90 days after discharge to those during the remainder of the year.
Treatment Effect With Paliperidone Palmitate Compared With Oral Antipsychotics in Black/African American Patients With Schizophrenia and a History of Criminal Justice System Involvement: A Post Hoc Analysis of the PRIDE Study
This study examined the use of injectable paliperidone palmitate in Black/African American patients with schizophrenia and prior criminal justice system involvement. Read it to see if treatment failures were reduced with paliperidone vs oral medications.
Convolutional Neural Network–Based Deep Learning Model for Predicting Differential Suicidality in Depressive Patients Using Brain Generalized q-Sampling Imaging
Even given known risk factors for suicide, predicting suicide is difficult. This study used deep learning of structural magnetic resonance imaging to create an algorithm for detecting suicidal ideation and suicidal attempts.
Therapeutic Potential of Psychedelics in the Treatment of Psychiatric Disorders, Part 1: Psychopharmacology and Neurobiological Effects
In addition to altering one’s perception of reality, psychedelics may be useful for treating certain psychiatric disorders. This brief review looks at the mechanisms behind their effects.
Homicide-Suicide in the United States: Moving Toward an Empirically Derived Typology
Incidents involving both a homicide and a suicide are rare and vary widely in terms of motive and circumstances. Read this study to learn about 8 classifications of homicide-suicides the authors developed using a large database.
Serum Fatty Acid Latent Classes Are Associated With Suicide in a Large Military Personnel Sample
Levels of several fatty acids (FAs) have been linked to suicidal behavior, though research has mainly focused on individual FAs. This study used latent class cluster analysis to identify groupings of FAs that may affect likelihood of suicidal behavior.
Pharmacotherapy for Attention-Deficit/Hyperactivity Disorder and Retention in Outpatient Substance Use Disorder Treatment: A Retrospective Cohort Study
How does comorbid attention-deficit/hyperactivity disorder (ADHD) affect individuals with substance use disorder (SUD)? Is treatment for ADHD associated with retention in outpatient SUD therapy?
Therapeutic Potential of Psychedelics in Treatment of Psychiatric Disorders, Part 2: Review of the Evidence
Could psychedelics such as psilocybin and LSD be useful in treating MDD or other psychiatric disorders? This brief review looks at the evidence.
Outcomes of Youth Treated With Electroconvulsive Therapy: A Retrospective Cohort Study
Electroconvulsive therapy (ECT) use in children and adolescents is much less common than in adults, and the evidence base for its use in youth is limited. This study reports outcomes of a cohort of youth treated with ECT at an academic medical center.
February 18, 2021
Risk Factors for Reattempt and Suicide Within 6 Months After an Attempt in the French ALGOS Cohort: A Survival Tree Analysis
Understanding risk factors for suicidal behavior is crucial for the development of effective prevention plans. Do anxiety disorders or alcohol use disorder play a role? Learn more in this CME activity.
N-Acetylcysteine Augmentation for Patients With Major Depressive Disorder and Bipolar Depression
Two recent meta-analyses found little effect of N-acetylcysteine augmentation in MDD or bipolar depression, although some past research has indicated its efficacy. In this article, Dr Andrade takes a closer look at whether the evidence supports its use.
HARKing, Cherry-Picking, P-Hacking, Fishing Expeditions, and Data Dredging and Mining as Questionable Research Practices
In this article, Dr Andrade helps readers identify several types of statistical analysis that violate scientific principles and that researchers may knowingly—or unknowingly—engage in.
January 19, 2021
Gratitude in a Year of Adversity
This editorial reflects on the unique challenges of the past year and recognizes peer reviewers for JCP in 2020.
Treatment Outcomes of Electroconvulsive Therapy for Depressed Patients With and Without Borderline Personality Disorder: A Retrospective Cohort Study
Borderline personality disorder (BPD) is thought to lead to poor response to electroconvulsive therapy (ECT) in depressed patients. This study assessed symptom-severity outcomes among depressed patients with and without comorbid BPD who received ECT.
Building Resilience Among Frontline Health Care Workers: Strategies to Consider for Implementing Evidence-Based Practices
This commentary discusses a recent brief report by Pietrzak et al and lists 3 strategies that health care systems could use to improve mental health support for frontline health care workers during the COVID-19 pandemic.
Predictors of Suicidal Ideation and Preparatory Behaviors in Individuals With Bipolar Disorder: The Contribution of Chronobiological Dysrhythmicity and Its Association With Hopelessness
Evidence has shown that bipolar disorder is often linked to alterations in circadian rhythms. This study looked at the impact of these rhythms on suicide risk, as well as the role of hopelessness, in patients with bipolar disorder.
Wrestling With Antidepressant Use in Bipolar Disorder: The Ongoing Debate
The question of whether, and when, antidepressants are appropriate in bipolar disorder is a hotly debated topic. This ASCP Corner article summarizes the key concepts with greatest relevance for clinical decision-making.
January 12, 2021
How Much Is the Debate Over Antidepressant Efficacy and Safety in Bipolar Depression an Artifact of Study Methodologies?
This editorial discusses a recent study of citalopram in bipolar depression and revisits the long-held assumption that antidepressants lead to poor outcomes in bipolar disorder.
Dr Andrade Replies
Here, Dr Andrade replies to a letter to the editor regarding a recent Clinical and Practical Psychopharmacology column on use of baclofen in alcohol use disorder patients.
Effects of Long-Acting Injectable Paliperidone Palmitate on Clinical and Functional Outcomes in Patients With Schizophrenia Based on Illness Duration
Although long-acting injectable (LAI) antipsychotics show benefit in the early stages of schizophrenia, they are mostly used later in the illness. This study assessed clinical and functional improvement with paliperidone LAI at different illness durations.
Citalopram for Acute and Preventive Efficacy in Bipolar Depression (CAPE-BD): A Randomized, Double-Blind, Placebo-Controlled Trial
Antidepressants are widely used to treat bipolar illness, though their effectiveness in this disorder has not been established. This randomized, double-blind, placebo-controlled trial assessed the efficacy and safety of citalopram in bipolar depression.
Optimal Long-Acting Injectable Antipsychotic Management During COVID-19
Long-acting injectable antipsychotics are effective for preventing relapse in schizophrenia, but in-person administration of them is a challenge during a pandemic. This report describes how a clinic successfully reduced in-person injections by 40%.
