Weekly Mind Reader: How ADHD Complicates Brain Development

by Denis Storey
August 9, 2024 at 8:25 AM UTC

This week, we dig into sex and antidepressants, a new approach to schizophrenia, and The Southwest Forum on Difficult to Treat Depression.

This edition of Weekly Mind Reader starts with a review of ADHD and child development, a case report of a man with musical hallucinations, and the story of an Olympian who struggled with an eating disorder

ADHD Kids Face Unique Challenges During Brain Development

Children with attention-deficit/hyperactivity disorder (ADHD) – who wage an endless war on divided attention, hyperactivity, and impulse control – also face a covert battle against developmental challenges. 

In a narrative review, appearing this week in Primary Care Companion for CNS Disorders, the authors attempt to make sense of this incredibly heterogeneous disorder, which presents in a variety of clinical profiles, travels along disparate trajectories, and shadows multiple comorbidities.

Adolescence – a phase of life already rife with intense, cognitive, emotional, and physical changes – presents greater challenges for kids with ADHD. And the move from child to adult mental health services can be difficult, exacerbated by ADHD’s symptoms and the functional impairments that might come with it. These challenges can act as a drag on care. To counter that, the authors advise bespoke management strategies for adolescents and young adults (AYAs) with ADHD.

As we all know, brain development in adolescence paves the way for the rest of one’s life. And the prefrontal cortex, with its command of executive functions, matures last. This can often translate into disparities with earlier-maturing brain regions, such as the limbic system, which can drive risk-taking behaviors.

Consequently, ADHD adolescents tend to take unnecessary risks that can include substance use, impulsive behaviors, and psychiatric comorbidities, complicating diagnosis and treatment. Puberty introduces additional challenges with its hormonal changes, which can make everything worse.

Effective management of ADHD in kids must leverage a multimodal approach, the authors argue, that integrates pharmacotherapy with psychosocial interventions. Adolescents with ADHD must adapt to take ownership of their condition, with support from parents and healthcare providers to ensure successful transitions into adulthood. This is particularly critical when it comes to medication adherence. 

IN OTHER PSYCHIATRY AND NEUROLOGY NEWS

  • Original research published in the Journal of Clinical Psychiatry suggests that the absence of substance use disorders is the strongest predictor of achieving recovery from borderline personality disorder.
  • A PCC case report discusses a 59-year-old man with no prior psychiatric history who developed musical hallucinations after the administration of methylprednisolone.
  • Additional JCP research confirms the reliability of CAPS-5 for subsequent PTSD development in the general injured population.
  • Another PCC case study shares the unique story of a 17-year-old boy who presented with sexsomnia and Dhat syndrome.
  • Finally, as the Olympics wind down, we feature the exclusive story of skier Alice Merryweather’s post-2018 Winter Games eating disorder and how it illustrates the often-hidden nature of these disorders in female athletes.

Original Research

Long-Term Safety, Tolerability, and Durability of Treatment Effect of Olanzapine and Samidorphan: Results of a 4-Year Open-Label Study

During up to 4 years of treatment, the combination of olanzapine/samidorphan was safe and well-tolerated, and patients’ symptoms remained stable.

Jacob S. Ballon and others

Letter to the Editor

Notice of Retraction: Gawash A, et al. Association of Body Dysmorphic–Induced Anabolic-Androgenic Steroid Use With Mental Health Outcomes: A Systematic Review. Prim Care Companion CNS Disord. 2023;25(5):23r03532.

Ahmed Gawash and others