Clozapine-Induced Euphoria: A Case Report

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To the Editor: We describe a case of treatment-resistant schizophrenia in which clozapine initiation and titration caused transient euphoria.

Case report. Mr A is a 64-year-old man with a 35-year history of treatment-refractory schizophrenia (DSM-IV criteria), who was experiencing chronic delusions and auditory and visual hallucinations. He underwent multiple trials of different antipsychotics in the past, including trifluoperazine, chlorpromazine, olanzapine, and haloperidol, with minimal improvement in the psychotic symptoms.