Letter to the Editor November 9, 2017

Exacerbation of Depression Symptoms in the Presence of Dermatitis Herpetiformis Rash, Celiac Disease, and Low Cholesterol

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Prim Care Companion CNS Disord 2017;19(6):17l02134

Article Abstract

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To the Editor: Dermatitis herpetiformis and celiac disease may be associated with mood disorders in some patients, with suggestions of a link between low levels of cholesterol. Exacerbation of depressive symptoms has been attributed to cholesterol alterations in nerve cell membranes needed to maintain the functional integrity of serotonin receptors.

Case report. Ms A is a 59-year-old white woman who presented with depression, frequent crying, insomnia, loss of concentration, and anhedonia for more than 2 weeks.