New Insights Into COVID-19 and Gratitude for Service

Larry Culpepper, MD, MPH

Published: February 24, 2022


Over the last 2 years, I have been amazed and encouraged by the response within the profession investigating patient and community needs related to the coronavirus disease 2019 (COVID-19) pandemic. We have seen a regular flow of reports and research regarding the impact of COVID-19 on patients and their clinicians as well as on communities across the globe. This information, while locally informative, has been to a great degree generalizable to settings with very different cultural and social influences. Manuscripts have described pandemic-related stressors and the mental health impact and clinical strategies in rural and urban groups; in hospital, ambulatory, and emergency clinical settings; in old and young patients; in immigrants, travelers, and students; in those well off or homeless; and in those with depression, anxiety, bipolar disorder, and psychotic illnesses. Hopefully, the breadth of such publications has helped caregivers adopt responses that can be effective with their evolving priorities.

What we are beginning to see—and will see for years if not decades to come—are manuscripts reporting new insights into how COVID-19 infections alter brain processes during acute infection and over the long term. These numerous and novel alterations include direct, immunologic, and vascular processes involving many of the neurotransmitters we have relied on for the past 50–70 years (eg, serotonin, dopamine, norepinephrine), as well as those that we are just beginning to use such as N-methyl-d-aspartate (ketamine) and glutamate. The alterations involve neurons, their brain networks and peripheral connections, glial cell changes, and vascular and blood-brain barrier interactions. We may find that familiar psychiatric medications are less effective when COVID-19 infection has altered neurophysiology, while other traditionally nonpsychiatric medications such as old and very new anti-inflammatory agents are more effective. We also may find that traditional diagnostic strategies to evaluate psychiatric symptoms and behaviors and dementing illness are insufficient to guide treatment and prognosis. To be effective, clinicians will be required to stay up to date as the research in this area develops and is synthesized into information to guide practice. The Primary Care Companion for CNS Disorders (PCC) will continue to serve as a conduit for clinically useful information for primary care and psychiatric practitioners and investigators.

The PCC remains committed to its mission to provide information relevant to clinical practice at the interface of primary care with psychiatry and neurology. We are indebted to the many authors whose contributions bring insights to you from all corners of the globe. If you are a clinician or investigator whose experience may be similarly valuable to our readers, you are invited to submit your research to the PCC.

I also want to thank our peer reviewers from the past year, whose skill in evaluating manuscripts and providing excellent feedback to authors is an often underrecognized contribution of time and expertise. Their valuable feedback on a broad range of content has resulted in manuscripts being modified, improved, and made more relevant to our readers. Our peer reviewers listed below provide the varied perspectives and feedback that ensure high quality in all manuscripts we accept. Please join us as we recognize their invaluable contribution to the PCC.

Larry Culpepper, MD, MPH
Editor in Chief

Figure 1

Ruchita Agrawal Hussein Akroos
Ali Al-Imam Behice Han Almis
Miruna Ates Tarun Bastiampillai
Manjeet S. Bhatia Bradford Bobrin
Joseph Boney Nileswar Das
Sandeep Grover Talib Manea
Mustafa Ramadhan James K. Rustad

Reviewers for the Primary Care Companion for CNS Disorders
January 1, 2021–December 31, 2021


Awais Aftab Himanshu Agrawal Ruchita Agrawal
Hussein Akroos Samir Al-Adawi Margarida Albuquerque
Muwafak Al-Eithan Bader Alenzi Mohammed Alhazza
Ali Al-Imam Danah Aljaafari Marcela Almeida
Behice Han Almis S. M. Yasir Arafat Rashmi Arasappa
Austin Armstrong Isha Arora Priti Arun
Miruna Ates Jacob Ballon Anuradha Baminiwatta
Pedro C. Barata Jacqueline Bartlett Salah Basheer
Alfredo Bellon Manjeet S. Bhatia Bradford Bobrin
Ermal Bojdani Joseph Boney James Bourgeois
Oscar Bukstein Katia Canenguez Stanley S. Caroff
Daniel Cho Jude Chukwuma Dan Cohen
Allegra Condiotte Mina Cvjetkovic-Bosnjak Nileswar Das
Subhash Das Migita D’Cruz Jose de Leon
Bahadır Demir Apoorva Deshpande Ailyn Diaz
Ana Duarte Recep Dursun Amir Bishay Elshokiry
Seyed Ali Enjoo Kathryn Erickson-Ridout Rodrigo Escalona
Jaqueline Eserian Andrea Fagiolini Michael Fana
Nuno Fernandes Guillaume Foldes-Busque Danielle Gainer
João Gama Marques Mohan Gautam Abhishek Ghosh
Priya Gopalan Angela Gough Sandeep Grover
Mayank Gupta Nitin Gupta Bishurul Hafi
Sina Hafizi Philip Harvey Hashim Talib Hashim
Taranjeet Jolly Holland Kaplan Bhaskar Katram
Zaira Khalid Samar Khalifa Gauri Khatkhate
Panagiota Korenis Sevda Korkmaz Rakesh Lal
Raphael Leo Anber Mahboob Subani Maheshwari
Yassir Mahgoub Estela Malatesta Talib Manea
André Ribeirinho Marques Prakash Masand Baraa Mazi
Victoria Milano Fatemeh Mirfazeli U. K. Misra
Pedro Modrego Mary Moller Debbie Morton
David Mota Jorge Mota Neda Motamedi
Mona Nada Naresh Nebhinani Daniel Neto
Amy Newhouse Violeta Nogueira Miriam Olivola
David Osser David Ozar Jose Pascual
Thaddeus Pope Pallavi Priyam Mustafa Ramadhan
Craig Richard Maxwell Rovner James K. Rustad
Kamaldeep Sadh Miguel íngel Sanchez-Gonzalez João Santos
Núria Santos Aparajita Satapathy Amal Satte
Parnika Saxena Rim Sellami Mujeeb Shad
Bilal Shah Leili Shahgholi Rizwana Shahid
Nidhi Sharoha Sonia Shenoy Ajeet Sidana
Jasbir Singh Kartik Singhai Colin Smith
Robert Smith Colette Solebo Sneha Sood
Anusha Sridharan Shruti Srivastava Gail Steketee
Debra Stultz Leah Susser Mercedes Szpunar
Hiroki Tanoue Taha Tuman Karl Umbrasas
Süheyla Ünal Mihir Upadhyaya Madhur Verma
Biju Viswanath Roopma Wadhwa Marcela Waisman
Nooshin Yoshany

Published online: February 24, 2022.

Prim Care Companion CNS Disord. 2022;24(1):PCC.22ed03261.

To cite: Culpepper L. New insights. Prim Care Companion CNS Disord. 2022;24(1):PCC.22ed03261.
To share:

© 2022 Physicians Postgraduate Press, Inc.

Volume: 24

Quick Links:


Buy this Article as a PDF