Psychotic Symptoms Associated With Superior Vena Cava Syndrome Following Methamphetamine Abuse

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To the Editor: Superior vena cava syndrome (SVCS) is a manifestation arising from compression or obstruction of the superior vena cava (SVC), characterized by edema of the face, neck, trunk, and upper extremities as well as collateral venous distension of the neck and anterior chest wall. Mostly caused by mediastinal malignancies, SVCS can be secondary to SVC thrombosis in 1%-5% of cases. Amphetamine-type stimulants have been extensively associated with psychiatric conditions, namely mood and psychotic episodes.