The article you requested is

Are Two Antidepressant Mechanisms Better Than One?

J Clin Psychiatry 1997;58(8):339-340

The classical antidepressants, namely tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors, have multiple pharmacologic mechanisms, but only those increasing the availability of serotonin (5-HT) and norepinephrine (NE) explain antidepressant actions. Their other actions, such as anticholinergic properties, are responsible for side effects.1 This profile has given rise to the notion that multiple mechanisms mean “dirty drugs” and that the best drugs should be “smart bombs” attacking only a single receptor target.