Balancing Risks: Dosing Strategies for Antidepressants Near the End of Pregnancy

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One of the most difficult balancing acts in clinical psychopharmacology practice is minimizing the risks of untreated depression in pregnant women while also minimizing the risks of antidepressant treatment. Major depression is estimated to occur in 9.4% to 12.7% of pregnant women1 and to recur in over two thirds of women who discontinue antidepressant medication while pregnant.2 Antenatal depressive symptoms can compromise outcomes for women and their offspring.3

J Clin Psychiatry 2008;69(2):323-324