ASCP Corner: Pulsed Intravenous Administration of Scopolamine Produces Rapid Antidepressant Effects and Modest Side Effects

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Scopolamine is an antimuscarinic agent and thus targets cholinergic muscarinic receptors. Currently, scopolamine is used primarily for postoperative nausea, gastrointestinal disorders, and motion sickness. Available formulations include intravenous (IV), oral, ophthalmologic, and transdermal. The involvement of the cholinergic neurotransmitter system in mood disorders is not new,1–4 but interest in this system as a potential target for antidepressant agents developed more recently.

J Clin Psychiatry 2013;74(8):850-851