Antidepressant Treatment of Posttraumatic Stress Disorder
Teri Pearlstein
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Recent large double-blind, placebo-controlled trials have indicated that sertraline is an effective and
well-tolerated treatment for posttraumatic stress disorder (PTSD). The avoidance/numbing symptom
cluster improved the most significantly with sertraline, but significant improvements were also noted
for the intrusive/reexperiencing and arousal symptom clusters. Smaller double-blind, placebo-controlled
trials have also indicated that fluoxetine is an effective treatment for PTSD. Multiple small, open studies
with other selective serotonin reuptake inhibitors and newer antidepressants indicate that these medications
show some promise. Older studies indicate some efficacy for tricyclic antidepressants, and monoamine
oxidase inhibitors are a reasonable choice, particularly for intrusive/reexperiencing symptoms.
J Clin Psychiatry 2000;61(suppl 7):40-43
© Copyright 2000 Physicians Postgraduate Press, Inc.
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