Introduction. Emerging Evidence in the Treatment of Depression and Chronic Pain in Primary Care: All Antidepressants Are Not Created Equal

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Depression is one of the leading causes of global disease burden and is expected to be the second leading cause within 2 decades.1There is a vast body of evidence to demonstrate the potential effects of untreated or inadequately treated depression, including an increased likelihood of negative outcomes in comorbid medical conditions2–5 and increased health care costs,6,7 as well as outcomes specific to depression, such as significant psychosocial impairment,6,8–10 an increased risk of relapse or recurrence, a longer time to recovery, and a shorter time between episodes.11–14​​

Prim Care Companion J Clin Psychiatry 2003;5(suppl 7):3-5