Systematic Review

Control Conditions in Randomized Trials of Psychedelics: An ACTTION Systematic Review

Systematic Review

Control Conditions in Randomized Trials of Psychedelics: An ACTTION Systematic Review

May 10, 2023

Randomized trials of psychedelics underutilize blind assessment, active drug controls, and testing psychological support against minimal-support conditions—elements that would improve quality or provide important information.

Eric C. Strain, Matthew W. Johnson, Sandeep M. Nayak, et al

Resilience in Bipolar Disorder

Systematic Review

Resilience in Bipolar Disorder

February 22, 2023

Bipolar disorder patients with greater resilience had less severe symptoms, more positive attitudes toward medication treatment, and better social support and functioning.

Kang Sim, Qian Hui Chew, Min Kai Chan

Substance Withdrawal and Takotsubo Cardiomyopathy

Systematic Review

Substance Withdrawal and Takotsubo Cardiomyopathy

February 21, 2023

Takotsubo cardiomyopathy should be suspected when patients develop atypical symptoms in the setting of substance withdrawal, including tachycardia, blood pressure changes, chest pain, dyspnea, and altered mental status.

Saeed Ahmed, Joji Suzuki, Danielle K. Back, et al

Impact of Paternal Depression on Children

Systematic Review

Impact of Paternal Depression on Children

February 7, 2023

An association exists between paternal mental health and depressive symptoms and neurodevelopmental disorders in infants and children.

Shailesh Jain, Zeeshan Mansuri, Bhumika Shah, et al

Managing Obstructive Sleep Apnea in Psychiatric Practice

Systematic Review

Managing Obstructive Sleep Apnea in Psychiatric Practice

January 23, 2023

As shown in this review, OSA may be a risk factor for the development of psychiatric conditions, as well as suicidal ideation and attempts.

Ruth M. Benca, Andrew Krystal, Craig Chepke, et al

Opioid Use Disorder and Its Treatment in the Elderly

Systematic Review

Opioid Use Disorder and Its Treatment in the Elderly

January 10, 2023

OUD may be particularly problematic in the elderly due to age-related pain syndromes and comorbidities that increase the risk of side effects, overdose, and death. This review assessed the...

Roopa Sethi, Jaya Sri Konakanchi

Impact of Treating Depression on Associated Comorbidities

Systematic Review

Impact of Treating Depression on Associated Comorbidities

January 3, 2023

Effective treatment of MDD may lead to a reduction in the severity of certain serious comorbidities. This review highlights the importance of appropriate and timely treatment of MDD.

Phyllis Foxworth, Alix M. Arnaud, Teri S. Brister, et al

Psychiatric Considerations in Pediatric Brain Tumors

Systematic Review

Psychiatric Considerations in Pediatric Brain Tumors

December 20, 2022

This review explores the factors associated with elevated depression and anxiety symptoms in adolescents with brain tumors, as well as various currently recommended interventions.

Jessie Benson, Ashish Sarangi

Relationship of PMDD and Bipolar Disorder

Systematic Review

Relationship of PMDD and Bipolar Disorder

October 26, 2022

In the 5 studies reviewed, 10%–15% of people with PMDD also had bipolar disorder, while 27%–76% of those with bipolar disorder also had PMDD.

Verinder Sharma, Dwight Mazmanian, Heidi Eccles

Combined Ketamine and Monoamine Oxidase Inhibitors

Systematic Review

Combined Ketamine and Monoamine Oxidase Inhibitors

October 24, 2022

Little is known about actual side effects of augmentation of ketamine to monoamine oxidase inhibitors (MAOIs). This systematic review and cases series evaluated symptoms of serotonin syndrome and hypertension...

Jolien K. E. Veraart, Sanne Y. Smith-Apeldoorn, Mats Kutscher, et al

Impact of Major Depressive Disorder on Comorbidities

Systematic Review

Impact of Major Depressive Disorder on Comorbidities

October 19, 2022

Associations between major depressive disorder (MDD) and comorbid disorders have been studied, but not all have been explored systematically. This study summarized observational data on the effect of MDD...

Alix M. Arnaud, Teri S. Brister, Ken Duckworth, et al

Fear Learning, Extinction Learning, and Reversal Learning in OCD

Systematic Review

Fear Learning, Extinction Learning, and Reversal Learning in OCD

October 5, 2022

Alterations in fear learning, extinction learning, and reversal learning are key processes in OCD. This review summarizes the research and its applications for optimizing OCD treatment.

Elizabeth R. Steuber, Joseph F. McGuire

Engagement by Race/Ethnicity in Mental Health Interventions

Systematic Review

Engagement by Race/Ethnicity in Mental Health Interventions

September 14, 2022

Observational studies show that individuals who are Black, Indigenous, and People of Color have less mental health care engagement than non-Latino Whites. This systematic review builds on those results...

Peter C. Lam, Danielle Simpson, Dolly A. John, et al

TMS for Schizophrenia Management

Systematic Review

TMS for Schizophrenia Management

August 25, 2022

In this review, the authors analyze all current literature related to different transcranial magnetic stimulation modalities in the management of schizophrenia symptoms.

Mujeeb U. Shad, Elham Soltani, Hamid Bateni

Psychodermatology Knowledge and Practice Patterns

Systematic Review

Psychodermatology Knowledge and Practice Patterns

July 26, 2022

This review analyzes the literature on psychodermatology knowledge, awareness, and practice patterns among dermatologists worldwide to better elucidate their educational needs and referral practices.

Mohammad Jafferany, Rachel E. Christensen

Umbilical Cord Blood Infusion and Autism Management

Systematic Review

Umbilical Cord Blood Infusion and Autism Management

June 2, 2022

In this review, the authors provide an overview of the role of umbilical cord blood in managing autism spectrum disorder symptoms in children aged 4–8 years.

Shailesh Jain, Zeeshan Mansuri, Chintan Trivedi, et al

Chronic Pain Treatment in Elderly Depressed Patients

Systematic Review

Chronic Pain Treatment in Elderly Depressed Patients

May 24, 2022

Here, the authors review the best pharmacologic and nonpharmacologic interventions in the management of chronic pain in elderly patients with depression.

Sasidhar Gunturu, Eric Garrels, Soroush Pakniyat-Jahromi, et al

Systematic Review

Cognitive Effects of Ketamine in Depression

January 4, 2022

The cognitive effects of ketamine have not been thoroughly investigated in depressed populations. This systematic review sought to determine the objective neurocognitive effects of ketamine in individuals with unipolar...

Sophie R. Vaccarino, Fathima Adamsahib, Roumen V. Milev, et al

Systematic Review

Clozapine Treatment During Pregnancy and the Postpartum Period

December 14, 2021

Clozapine is the only agent with proven efficacy for treatment-resistant schizophrenia, but is it safe for pregnant women? This article synthesizes the existing evidence.

Marieke M. Beex-Oosterhuis, Arthur R. Van Gool, Eibert R. Heerdink, et al

Systematic Review

Social Fragmentation and Schizophrenia

December 7, 2021

Lack of social integration and inclusion may be an important determinant of incidence of psychosis. This systematic review explores the relationship between psychosis and area-level social fragmentation.

Benson S. Ku, Michael T. Compton, Elaine F. Walker, et al

Systematic Review

Treating ECT-Emergent Hypomania and Mania

November 16, 2021

Evidence-based guidelines for managing ECT-emergent hypomania/mania are lacking. This systematic literature review compiled the current published literature on treating ECT-emergent hypomania/mania to help guide treatment course in depressed patients.

Alesia A. Cloutier, Stephen J. Seiner, Haley V. Solomon, et al

Systematic Review

Ketamine and Risk of Psychosis in Vulnerable Patients

July 13, 2021

Psychotic features are an exclusion criterion in most ketamine treatment studies given the assumption that ketamine use increases psychosis. This systematic review examined whether this assumption holds true in...

Jolien K. E. Veraart, Sanne Y. Smith-Apeldoorn, Jan Spijker, et al

Systematic Review

Complex Polypharmacy in Bipolar Disorder

June 1, 2021

Complex pharmacotherapy is common in patients with bipolar disorder. This study examined the prevalence of such complex regimens in bipolar disorder patients and sought to characterize factors that influence...

Anna M. Kim, Lisa Salstein, Joseph F. Goldberg

Systematic Review

ECT as a Treatment for Somatization Disorder

May 20, 2021

Is ECT an effective treatment option for severe and refractory manifestations of somatization disorder? In this review, the authors investigate the efficacy, safety, and tolerability of ECT in somatization...

Ahmed Saeed Yahya, Shakil Khawaja

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