Andrew D. Krystal, MD

Idiopathic Hypersomnia: Recognition and Management in Psychiatric Practice

June 2, 2025

Idiopathic hypersomnia, characterized by excessive daytime sleepiness (EDS), has an estimated population prevalence up to 1.5%. Psychiatric medications may exacerbate EDS and, conversely, idiopathic hypersomnia treatments may exacerbate psychiatric...

Craig Chepke, Ruth M. Benca, Andrew J. Cutler, et al

Academic Highlights

Diagnosing and Treating Adult Insomnia

September 28, 2021

Drs Rosenberg and Krystal identify key steps in the diagnosis and treatment of insomnia disorder.

Andrew D. Krystal, Russell P. Rosenberg

Educational Activity

Optimizing Treatment for Insomnia

July 13, 2021

Dr Krystal describes a new paradigm for managing insomnia in which clinicians can select interventions that best target the sleep problem of each patient. The result is an improved...

Andrew D. Krystal

Educational Activity

Managing Insomnia in Older People

June 29, 2021

Do your older patients experience insomnia? Dr Krystal offers general considerations and specific data related to managing insomnia in older adults, including tolerability of treatment options.

Andrew D. Krystal

Consensus Statement

Consensus Recommendations for Applying rTMS in MDD

May 23, 2017

To quell any confusion on how best to apply rTMS to treat patients with major depressive disorder, the NNDC's rTMS Task Group and members of the APA's Council on...

Mustafa M. Husain, Shirlene M. Sampson, Linda L. Carpenter, et al

Article

Brexpiprazole in MDD and Sleep Disturbances

September 8, 2016

Sleep disturbance in major depressive disorder predicts poorer clinical outcomes and is an independent risk factor for suicide. Read the results of this study that evaluated the effects of...

Ross A. Baker, Andrew D. Krystal, Aurélia Mittoux, et al

Original Research

Sleep Disturbance in Chronic Military-Related PTSD: Clinical Impact and Response to Adjunctive Risperidone in the Veterans Affairs Cooperative Study #504

April 27, 2016

Robert A. Rosenheck, Robert H. Pietrzak, Andrew D. Krystal, et al

Educational Activity

Recognizing and Managing Insomnia in Primary Care and Specialty Settings

April 27, 2016

Andrew D. Krystal, Adam J. Sorscher

Educational Activity

Current, Emerging, and Newly Available Insomnia Medications

August 26, 2015

Andrew D. Krystal

Supplement Article

Orexin and the Sleep-Wake Cycle

September 15, 2013

What is the sleep-wake cycle? Read a case explaining the roles of sleep and the orexin system and how that relates to insomnia.

Andrew D. Krystal, Ruth M. Benca, Thomas S. Kilduff

Educational Activity

Shift Work Disorder Case Studies: Applying Management Principles in Clinical Practice

August 15, 2012

Andrew D. Krystal, Thomas Roth, Richard D. Simon, Jr

Article

Eszopiclone Treatment for Insomnia: Effect Size Comparisons in Patients With Primary Insomnia and Insomnia With Medical and Psychiatric Comorbidity

July 5, 2012

Review results from a post hoc analysis that compared the treatment effect size of eszopiclone 3 mg for insomnia in patients with a diagnosis of primary insomnia and in...

Maurizio Fava, Claudio N. Soares, Andrew D. Krystal, et al

Idiopathic Hypersomnia: Recognition and Management in Psychiatric Practice

Diagnosing and Treating Adult Insomnia

Optimizing Treatment for Insomnia

Managing Insomnia in Older People

Consensus Recommendations for Applying rTMS in MDD

Brexpiprazole in MDD and Sleep Disturbances

Sleep Disturbance in Chronic Military-Related PTSD: Clinical Impact and Response to Adjunctive Risperidone in the Veterans Affairs Cooperative Study #504

Recognizing and Managing Insomnia in Primary Care and Specialty Settings

Current, Emerging, and Newly Available Insomnia Medications

Orexin and the Sleep-Wake Cycle

Shift Work Disorder Case Studies: Applying Management Principles in Clinical Practice

Eszopiclone Treatment for Insomnia: Effect Size Comparisons in Patients With Primary Insomnia and Insomnia With Medical and Psychiatric Comorbidity

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Andrew D. Krystal, MD

Idiopathic Hypersomnia: Recognition and Management in Psychiatric Practice

Diagnosing and Treating Adult Insomnia

Optimizing Treatment for Insomnia

Managing Insomnia in Older People

Consensus Recommendations for Applying rTMS in MDD

Brexpiprazole in MDD and Sleep Disturbances

Sleep Disturbance in Chronic Military-Related PTSD: Clinical Impact and Response to Adjunctive Risperidone in the Veterans Affairs Cooperative Study #504

Recognizing and Managing Insomnia in Primary Care and Specialty Settings

Current, Emerging, and Newly Available Insomnia Medications

Orexin and the Sleep-Wake Cycle

Shift Work Disorder Case Studies: Applying Management Principles in Clinical Practice

Eszopiclone Treatment for Insomnia: Effect Size Comparisons in Patients With Primary Insomnia and Insomnia With Medical and Psychiatric Comorbidity

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