Charles F. Reynolds III, MD

  • 31Articles
  • 120.7KReads
  • 1997–2025Active
  • 132Collaborators
  • 605Citations

About

Charles F. Reynolds III, MD, is affiliated with the Department of Psychiatry at the University of Pittsburgh School of Medicine. With a publication record from 1997 to 2025, Reynolds has contributed extensively to the study of depression, particularly major depressive disorder in geriatric populations, as well as suicide risk, anxiety, posttraumatic stress disorder, and pain management. His work includes research on treatment outcomes, neurobiological mechanisms, and prevention strategies for late-life mental health conditions. Reynolds has frequently collaborated with authors such as Benoit H. Mulsant and M. Katherine Shear.

Publications

JCP
Actigraphy-Measured Sleep/Wake Characteristics Associated With Suicidal Ideation in Older Adults With Depression and High Suicide Risk
Original Research

Actigraphy-Measured Sleep/Wake Characteristics Associated With Suicidal Ideation in Older Adults With Depression and High Suicide Risk

July 14, 2025

Measures of sleep/wake rhythm disruption were independently associated with higher level of suicidal ideation in this sample of older adults at high risk for suicide.
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JCP
Vitamin D3 and Omega-3 Fatty Acids for Depression Prevention
Original Research

Vitamin D3 and Omega-3 Fatty Acids for Depression Prevention

June 26, 2023

Although several lines of evidence suggest that vitamin D3 and omega-3 fatty acids promote mood health, neither supplement showed benefits for indicated and selective prevention of late-life depression.
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JCP
Social Support and Symptoms of PTSD
Original Research

Social Support and Symptoms of PTSD

May 29, 2023

Social support affects the development and persistence of PTSD. A sense of belongingness to family and/or friends was associated with fewer PTSD symptoms in older adults.
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JCP
Original Research

Posttraumatic Distress and Prolonged Grief Disorder

April 20, 2021

Posttraumatic stress disorder and prolonged grief disorder (PGD) both arise following major life stressors. This study examined the presence and response to treatment of posttraumatic stress symptoms in bereaved...
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PCC
Original Research

Mental Health Consultation for Rural Older Adults With Depression and Pain

March 18, 2021

Novel approaches are needed to assist rural primary care physicians in caring for older patients living with depression and pain who are at an elevated suicide risk. Read this...
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JCP
Original Research

Benzodiazepines in Older Adults Receiving Antidepressants for Anxiety and Depression

September 29, 2020

This analysis of data from 2 clinical trials examined the effect of benzodiazepines on outcomes in older patients with generalized anxiety disorder or major depressive disorder, including the likelihood...
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JCP
Original Research

Predicting Remission in Late-Life Depression

December 10, 2019

Rates of treatment resistance in randomized controlled trials in patients with late-life depression are as high as 77% using SSRIs, yet SSRIs are often used as first-line treatment. This...
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JCP
Original Research

Cerebral Blood Flow After Late-Life Depression Treatment

October 23, 2018

Could cerebrovascular disease be a factor in your elderly patient's depression? This article investigated the association of white matter hyperintensities and cerebral blood flow with late-life depressive symptoms and...
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JCP
Original Research

Safety, Tolerability, and Clinical Effect of Low-Dose Buprenorphine for Treatment-Resistant Depression in Midlife and Older Adults

August 26, 2014

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JCP
Article

Response to Antidepressant Medications in Late-Life Depression Across the Spectrum of Cognitive Functioning

February 15, 2014

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PCC
Article

Consensus Statement on Depression in the Elderly

April 18, 2013

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JCP
Original Research

Insomnia and Objectively Measured Sleep Disturbances Predict Treatment Outcome in Depressed Patients Treated With Psychotherapy or Psychotherapy-Pharmacotherapy Combinations

November 29, 2011

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Physicians Postgraduate Press, Inc. (PPP) makes no warranties about the accuracy or completeness of any information published in The Journal of Clinical Psychiatry or other PPP materials, and disclaims liability for any use or non-use of that information. Clinicians should not rely solely on these materials and should exercise their own professional judgment when making patient care decisions on an individualized basis.

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