Edward V. Nunes, MD

Early Change in Depressive Symptom Severity with Naltrexone-Bupropion Combination and Its Association with Reduction in Methamphetamine Use: ADAPT-2 Trial

July 30, 2025

Improvement in depression accounted for approximately 25% of the treatment effect of naltrexone-bupropion on methamphetamine treatment response.

Manish K. Jha, Udi E. Ghitza, Steve Shoptaw, et al

Original Research

Exercise vs Health Education for Treating Stimulant Use Disorder

February 14, 2017

Early evidence suggests that exercise may be an effective treatment approach for stimulant use disorders. Here, find out if exercise was superior to a health education intervention in reducing...

Madhukar H. Trivedi, Tracy L. Greer, Robrina Walker, et al

Original Research

Generalizability in Clinical Trials of Substance Abuse

January 25, 2017

If clinical trials by design exclude as many as 85% of individuals with a target disorder, how can these studies be representative of the clinical population? Discover in this...

Carlos Blanco, Mark Olfson, Edward V. Nunes, et al

Original Research

Treating Nicotine Dependence by Targeting Attention-Deficit/ Hyperactivity Disorder (ADHD) With OROS Methylphenidate: The Role of Baseline ADHD Severity and Treatment Response

October 15, 2013

Edward V. Nunes, Theresa M. Winhusen, Eugene C. Somoza, et al

Original Research

Exercise and Mental Illness: Results From the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)

July 15, 2012

Carlos Blanco, Shang-Min Liu, Edward V. Nunes, et al

Original Research

Differences Among Major Depressive Disorder With and Without Co-occurring Substance Use Disorders and Substance-Induced Depressive Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions

March 20, 2012

Carlos Blanco, Analucía A. Alegría, Shang-Min Liu, et al

Original Research

Comorbidity of Generalized Anxiety Disorder and Substance Use Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions

September 15, 2010

Carlos Blanco, Bridget F. Grant, Analucía A. Alegría, et al

Original Research

Long-Acting Injectable Versus Oral Naltrexone Maintenance Therapy With Psychosocial Intervention for Heroin Dependence: A Quasi-Experiment

July 13, 2010

Charles P. O' Brien, Edward V. Nunes, Adam C. Brooks, et al

Original Research

Generalizability of Clinical Trial Results for Major Depression to Community Samples: Results From the National Epidemiologic Survey on Alcohol and Related Conditions

August 31, 2008

Carlos Blanco, Mark Olfson, Renee D. Goodwin, et al

Original Research

Independent vs. Substance-Induced MDD

October 16, 2006

Read the full examination whether diagnoses of independent or substance-induced depression predict 1-year course of depression in patients.

Edward V. Nunes, Xinhua Liu, Sharon Samet, et al

Original Research

"Outer-Directed Irritability": A Distinct Mood Syndrome in Explosive Youth With a Disruptive Behavior Disorder?

June 15, 2003

Frederic M. Quitkin, Jonathan W. Stewart, Edward V. Nunes, et al

Letter to the Editor

Reversible Parkinsonism in a 90-Year-Old Man Taking Sertraline

June 15, 1997

Edward V. Nunes, Daniel S. Schechter

Early Change in Depressive Symptom Severity with Naltrexone-Bupropion Combination and Its Association with Reduction in Methamphetamine Use: ADAPT-2 Trial

Exercise vs Health Education for Treating Stimulant Use Disorder

Generalizability in Clinical Trials of Substance Abuse

Treating Nicotine Dependence by Targeting Attention-Deficit/ Hyperactivity Disorder (ADHD) With OROS Methylphenidate: The Role of Baseline ADHD Severity and Treatment Response

Exercise and Mental Illness: Results From the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)

Differences Among Major Depressive Disorder With and Without Co-occurring Substance Use Disorders and Substance-Induced Depressive Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions

Comorbidity of Generalized Anxiety Disorder and Substance Use Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions

Long-Acting Injectable Versus Oral Naltrexone Maintenance Therapy With Psychosocial Intervention for Heroin Dependence: A Quasi-Experiment

Generalizability of Clinical Trial Results for Major Depression to Community Samples: Results From the National Epidemiologic Survey on Alcohol and Related Conditions

Independent vs. Substance-Induced MDD

"Outer-Directed Irritability": A Distinct Mood Syndrome in Explosive Youth With a Disruptive Behavior Disorder?

Reversible Parkinsonism in a 90-Year-Old Man Taking Sertraline

ELSEWHERE:

FOLLOW US:

Edward V. Nunes, MD

Early Change in Depressive Symptom Severity with Naltrexone-Bupropion Combination and Its Association with Reduction in Methamphetamine Use: ADAPT-2 Trial

Exercise vs Health Education for Treating Stimulant Use Disorder

Generalizability in Clinical Trials of Substance Abuse

Treating Nicotine Dependence by Targeting Attention-Deficit/ Hyperactivity Disorder (ADHD) With OROS Methylphenidate: The Role of Baseline ADHD Severity and Treatment Response

Exercise and Mental Illness: Results From the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)

Differences Among Major Depressive Disorder With and Without Co-occurring Substance Use Disorders and Substance-Induced Depressive Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions

Comorbidity of Generalized Anxiety Disorder and Substance Use Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions

Long-Acting Injectable Versus Oral Naltrexone Maintenance Therapy With Psychosocial Intervention for Heroin Dependence: A Quasi-Experiment

Generalizability of Clinical Trial Results for Major Depression to Community Samples: Results From the National Epidemiologic Survey on Alcohol and Related Conditions

Independent vs. Substance-Induced MDD

"Outer-Directed Irritability": A Distinct Mood Syndrome in Explosive Youth With a Disruptive Behavior Disorder?

Reversible Parkinsonism in a 90-Year-Old Man Taking Sertraline

Watch the New PsychCase360

Subscribe to readmore articles

Subscribe to read
more articles