Edward V. Nunes, MD

JCP
Early Change in Depressive Symptom Severity with Naltrexone-Bupropion Combination and Its Association with Reduction in Methamphetamine Use: ADAPT-2 Trial
Original Research

Early Change in Depressive Symptom Severity with Naltrexone-Bupropion Combination and Its Association with Reduction in Methamphetamine Use: ADAPT-2 Trial

July 30, 2025

Improvement in depression accounted for approximately 25% of the treatment effect of naltrexone-bupropion on methamphetamine treatment response.
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JCP
Original Research

Exercise vs Health Education for Treating Stimulant Use Disorder

February 14, 2017

Early evidence suggests that exercise may be an effective treatment approach for stimulant use disorders. Here, find out if exercise was superior to a health education intervention in reducing...
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JCP
Original Research

Generalizability in Clinical Trials of Substance Abuse

January 25, 2017

If clinical trials by design exclude as many as 85% of individuals with a target disorder, how can these studies be representative of the clinical population? Discover in this...
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JCP
Original Research

Treating Nicotine Dependence by Targeting Attention-Deficit/ Hyperactivity Disorder (ADHD) With OROS Methylphenidate: The Role of Baseline ADHD Severity and Treatment Response

October 15, 2013

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JCP
Original Research

Exercise and Mental Illness: Results From the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)

July 15, 2012

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JCP
Original Research

Differences Among Major Depressive Disorder With and Without Co-occurring Substance Use Disorders and Substance-Induced Depressive Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions

March 20, 2012

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JCP
Original Research

Comorbidity of Generalized Anxiety Disorder and Substance Use Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions

September 15, 2010

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JCP
Original Research

Long-Acting Injectable Versus Oral Naltrexone Maintenance Therapy With Psychosocial Intervention for Heroin Dependence: A Quasi-Experiment

July 13, 2010

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JCP
Original Research

Generalizability of Clinical Trial Results for Major Depression to Community Samples: Results From the National Epidemiologic Survey on Alcohol and Related Conditions

August 31, 2008

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JCP
Original Research

Independent vs. Substance-Induced MDD

October 16, 2006

Read the full examination whether diagnoses of independent or substance-induced depression predict 1-year course of depression in patients.
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JCP
Original Research

"Outer-Directed Irritability": A Distinct Mood Syndrome in Explosive Youth With a Disruptive Behavior Disorder?

June 15, 2003

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JCP
Letter to the Editor

Reversible Parkinsonism in a 90-Year-Old Man Taking Sertraline

June 15, 1997

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