Paula Bolton, MS, CNP

Psychiatric Neurotherapeutics Program, McLean Hospital, Belmont, Massachusetts

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About

Paula Bolton, MS, CNP, is affiliated with the Psychiatric Neurotherapeutics Program at McLean Hospital in Belmont, Massachusetts. Bolton has published on treatment-resistant depression, focusing on comparative effects of repeated ketamine infusion versus intranasal esketamine. Collaborators include Amanda Sedgewick, Brian Boyle, Courtney Miller, Danika Dai, and Robert Meisner. Publications appear in Psychiatrist.com (The Journal of Clinical Psychiatry and The Primary Care Companion for CNS Disorders).

Publications

JCP
Comparative Effects of Repeated Ketamine Infusion vs Intranasal Esketamine in Patients with Treatment Resistant Depression: A Retrospective Chart Review
Original Research

Comparative Effects of Repeated Ketamine Infusion vs Intranasal Esketamine in Patients with Treatment Resistant Depression: A Retrospective Chart Review

September 22, 2025

In this naturalistic sample of patients with similarly severe treatment resistant depression treated over a 4- to 5-week induction period, intravenous racemic ketamine was associated with more rapid response...
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