Case Series
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Case Series
Esketamine Augmented With Dextromethorphan/Bupropion for Treatment Resistant Depression: A Case Series
November 3, 2025
Three patients with TRD who had no or partial response to esketamine monotherapy as part of a clinical trial received augmentation with dextromethorphan/bupropion 45 mg/105 mg daily.
Case Series
Alzheimer’s Dementia Confirmed by FDG-PET After Negative Neuropsychological Tests
December 17, 2024
This case series presents several patients who underwent formal neuropsychological testing that did not diagnose dementia, but whose clinical course and neuroimaging findings were consistent with the diagnosis.
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Case Series
Dexmedetomidine for Agitation With Excited Catatonia
October 7, 2021
The α2-receptor agonist dexmedetomidine is generally used for short-term analgesia and sedation. This report describes several cases in which dexmedetomidine was used to treat agitation that accompanied excited catatonia.
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Negative Symptoms May Predict Who Responds to Xanomeline-Trospium in Schizophrenia
October 8, 2026
Mike Halassa describes negative symptoms in schizophrenia and discusses clinical and post-hoc evidence that potentially suggests negative symptoms may be a useful clinical feature to look for when considering...
Case Series
Neuroinfectious Disease, Frontotemporal Neurocircuitry, and Cognitive and Affective Processing
November 4, 2021
Infectious lesions can disrupt neurocircuitry and cause loss of function. Here, the authors present 3 cases that underscore the need for awareness of long-lasting neuropsychiatric complications of brain infections.
