Major Depressive Disorder (MDD) is a debilitating condition characterized by persistent feelings of sadness, hopelessness, and a lack of interest in daily activities. Understanding its underlying causes and effective treatments is crucial for patient well-being. The Journal of Clinical Psychiatry provides a comprehensive look into MDD, offering evidence-based therapeutic approaches and the latest research findings. Our expert editors ensure content is relevant and actionable, aiding psychiatrists in offering holistic care to those grappling with depression.
Depression and Major Depressive Disorder
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Recently published articles about Depression (MDD)
Original Research
Efficacy and Safety of AXS-05 (Dextromethorphan-Bupropion) in MDD
May 30, 2022
Altered glutamatergic neurotransmission has been implicated in the pathogenesis of depression. This phase 3 trial evaluated the efficacy and safety of AXS-05 (dextromethorphan-bupropion) in the treatment of major depressive...
Clinical and Practical Psychopharmacology
Antidepressant Drugs and Health-Related QoL: A Guide to Examining a “Viral” Research Paper
May 25, 2022
A recent study reporting no improvement in health-related quality of life with antidepressants went “viral” in the mass media. Here, Dr Andrade considers the shortcomings of the study and...
Insights
Measurement-Based Care for Depressive Disorders: Meta-Analysis of RCTs Shows Efficacy
May 17, 2022
Dr Lam explains in this video how for patients with depressive disorders treated with pharmacotherapy, measurement-based care is effective in decreasing symptom severity, promoting remission, and improving medication adherence.
ASCP Corner
A Practical Guide for Tailoring Treatment Choices in Interventional Psychiatry
May 4, 2022
When 2 or more antidepressant trials have failed in patients with MDD, what comes next? This article compares 3 next-step interventions—TMS, esketamine/ketamine, and ECT—with a focus on incorporating the...
Clinical and Practical Psychopharmacology
Insights on Use of Ketamine From RCTs of Ketamine vs Electroconvulsive Therapy in Severe Depression
March 28, 2022
ECT outperformed ketamine in recent randomized controlled trials. These studies also, however, shed light on ketamine’s potential as a viable alternative to ECT in some severely depressed patients.
Original Research
Quetiapine XR in Comorbid Depression and Anxiety
March 21, 2022
Quetiapine is often used off-label for anxiety and as an augmentation agent in treatment-resistant depression. This study evaluated the efficacy and tolerability of quetiapine in augmenting first-line antidepressants for...
