Major Depressive Disorder (MDD) is a debilitating condition characterized by persistent feelings of sadness, hopelessness, and a lack of interest in daily activities. Understanding its underlying causes and effective treatments is crucial for patient well-being. The Journal of Clinical Psychiatry provides a comprehensive look into MDD, offering evidence-based therapeutic approaches and the latest research findings. Our expert editors ensure content is relevant and actionable, aiding psychiatrists in offering holistic care to those grappling with depression.
Depression and Major Depressive Disorder
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Recently published articles about Depression (MDD)
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    Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report
July 14, 2025
History of ECT use (lifetime and current episode) or TMS use (current episode) was prognostic of poorer outcomes across the total sample and superior benefit from active versus sham...
                    
                
            
           
            
            
            
        
			                Original Research
			
            
                
    Differentiating Subtypes of MDD Using Serum Biomarkers
June 23, 2025
Significant differences in biomarker profiles were observed across MDD subtypes: the melancholic subtype showed higher cortisol levels and lower serotonin levels, and the atypical subtype showed elevated levels of...