Major Depressive Disorder (MDD) is a debilitating condition characterized by persistent feelings of sadness, hopelessness, and a lack of interest in daily activities. Understanding its underlying causes and effective treatments is crucial for patient well-being. The Journal of Clinical Psychiatry provides a comprehensive look into MDD, offering evidence-based therapeutic approaches and the latest research findings. Our expert editors ensure content is relevant and actionable, aiding psychiatrists in offering holistic care to those grappling with depression.
Depression and Major Depressive Disorder
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Recently published articles about Depression (MDD)
Original Research
Aripiprazole or Bupropion Augmentation vs Switching to Bupropion in Treatment Resistant Depression
September 22, 2025
In this model, augmentation with bupropion better balanced efficacy and tolerability in TRD in adults under 85 than did switching to bupropion or augmentation with aripiprazole. Augmentation with aripiprazole...
Original Research
Comparative Effects of Repeated Ketamine Infusion vs Intranasal Esketamine in Patients with Treatment Resistant Depression: A Retrospective Chart Review
September 22, 2025
In this naturalistic sample of patients with similarly severe treatment resistant depression treated over a 4- to 5-week induction period, intravenous racemic ketamine was associated with more rapid response...
Original Research
Relationships between Prenatal Body Composition and Mental Health Are Moderated by Physical Activity and Diet
September 15, 2025
Higher body fat mass during pregnancy is associated with more depression and anxiety symptoms. However, physical activity and adherence to high-quality diets can lessen these effects.
