Clomipramine Treatment of Panic Disorder: Pros and Cons

Article Abstract

Background: Controlled trials suggest that clomipramine may be a highly effective antipanic drug. Lowering the starting dose may alleviate troublesome initial side effects and increase acceptability and compliance.

Method: Fifty-eight patients with DSM-III-R panic disorder with or without agoraphobia underwent 13 weeks of clomipramine treatment. Starting at 10 mg/day, the dose was gradually increased to a mean dose of 97 mg/day.

Results: While completers showed highly significant improvement, the benefits were severely limited by a high dropout rate due to adverse reactions occurring mostly during the first 2 weeks of treatment.

Conclusion: Given the alternatives, clomipramine should not be used as a first-line antipanic medication.

Volume: 58

Quick Links: Anxiety , Panic Disorder

Continue Reading…

Subscribe to read the entire article


Buy this Article as a PDF

Sign-up to stay
up-to-date today!


Already registered? Sign In

Original Research

Recovering From Intimate Partner Violence Through Strengths and Empowerment: Findings From a Randomized Clinical Trial

This RCT focused on a psychosocial counseling intervention for women experiencing intimate partner violence (IPV). Outcomes such...