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Original Articles

Fluvoxamine Attenuates Panic Induced by 35% CO2 Challenge

Henk J. Pols, MD; Roos C. Hauzer, MD; Jaap A. Meijer, MD; Kees Verburg, MD; and Eric J. Griez, MD

Published: November 15, 1996

Article Abstract

Background: The authors investigated whether 6 weeks of treatment with fluvoxamine would decrease the anxiogenic response to the 35% CO2 challenge in 11 patients with DSM-IIIR panic disorder with agoraphobia.

Method: The patients underwent a 35% CO2 challenge at baseline and again after 6 weeks of fluvoxamine treatment.

Results: The anxiogenic effect of CO2 was significantly (p < .05) reduced during fluvoxamine treatment.

Conclusion: The results suggest a relationship between the anxiogenic effect of CO2 and the therapeutic effect of fluvoxamine.

Volume: 57

Quick Links: Anxiety , Panic Disorder

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