This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Original Research

Benzodiazepine Use and Driving: A Meta-Analysis

Mark J. Rapoport, Krista L. Lanctôt, David L. Streiner, Michel B.édard, Evelyn Vingilis, Brian Murray, Ayal Schaffer, Kenneth I. Shulman, and Nathan Herrmann

Published: April 21, 2009

Article Abstract

Objective: The purpose of the present study was to examine the experimental and epidemiologic evidence linking benzodiazepine use to driving impairment.

Data Sources: We searched MEDLINE, PsycINFO, the Cochrane Collaboration, and EMBASE using the key terms (“benzodiazepines” OR “exp benzodiazepines“) AND (“automobile driving” OR “accidents, traffic” OR “driving” OR “driver$“) and limited the results to English citations from 1966 to August 5, 2005, with auto-updates for MEDLINE and PsycINFO to November 30, 2007.

Study Selection and Data Extraction: Experimental studies using driving simulators and on-road tests were sought, as were epidemiologic studies of a case-control or cohort design. Data were extracted by blinded raters and pooled using random-effects models. We excluded studies without control groups or without measures of driving or collisions. Studies with driving measures that could not be combined were also excluded.

Data Synthesis: Of 405 potential articles, 11 epidemiologic and 16 experimental studies were included in the meta-analysis. Associations between motor vehicle collisions (MVCs) and benzodiazepine use were found among 6 case-control studies (OR = 1.61, 95% CI = 1.21 to 2.13, p

Conclusion: Benzodiazepine users were found to be at a significantly increased risk of MVCs compared to nonusers, and these differences may be accounted for by a difficulty in maintaining road position.

Volume: 70

Quick Links:

Continue Reading…

Subscribe to read the entire article


Buy this Article as a PDF