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Original Articles

Electroconvulsive Therapy Decreases Dopamine D2 Receptor Binding in the Anterior Cingulate in Patients With Depression: A Controlled Study Using Positron Emission Tomography With Radioligand [11C]FLB 457

Tomoyuki Saijo, MD, PhD; Akihiro Takano, MD, PhD; Tetsuya Suhara, MD, PhD; Ryosuke Arakawa, MD, PhD; Masaki Okumura, MD; Tetsuya Ichimiya, MD, PhD; Hiroshi Ito, MD, PhD; and Yoshiro Okubo, MD, PhD

Published: June 15, 2010

Article Abstract

Results: There were no significant differences in D2 receptor binding between patients with MDD and controls. All 7 patients showed clinical improvements in response to ECT treatment (P‘ ‰<‘ ‰.001). Significant changes in D2 receptor binding, a mean of 25.2% reduction, were found in the right rostral anterior cingulate (AC) following ECT (P‘ ‰<‘ ‰.001).

Volume: 71

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