This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Original Research

Excretion of Paroxetine Into Breast Milk

Robert Ohman, Staffan Hagg, Lena Carleborg, and Olav Spigset

Published: August 1, 1999

Article Abstract

Background: The study was carried out to quantify the excretion of the selective serotonin reuptake inhibitor paroxetine in breast milk.

Method: In 6 lactating women, the concentrations of paroxetine in breast milk and serum were studied at the times for assumed minimum (24 hours after dose intake) and maximum (4-7 hours after dose intake) drug levels in milk. Moreover, a seventh subject was studied with frequent and regular sampling throughout a dose interval of 24 hours at 2 different dose levels.

Results: The mean milk/serum concentration ratios in the first 6 subjects ranged from 0.39 to 1.11 (overall mean ± SD = 0.69 ± 0.29), and the mean estimated dose to the infants ranged from 0.7% to 2.9% (overall mean ± SD = 1.4% ± 0.79%) of the weight-adjusted maternal dose. Based on area-under-the-curve data from the seventh subject, the milk/serum concentration ratio was 0.69 at a dose of 20 mg/day and 0.72 at a dose of 40 mg/day; the estimated relative doses to the infant were 1.0% and 2.0%, respectively. The mean increase in milk paroxetine concentrations from assumed minimum to assumed maximum was 61% (range, 4%-172%; p < .01). The mean paroxetine concentration in hindmilk was 78% higher than in foremilk (range, 16%-169%; p < .01), an increase that was parallel to the increase in milk triglyceride levels (r = 0.83, p = .005). No adverse drug reactions or unusual behaviors were reported in the infants.

Conclusion: The study indicates that the relative dose to a suckling infant for paroxetine is lower than that reported for fluoxetine and citalopram and higher than that reported for sertraline and fluvoxamine.

Volume: 60

Quick Links:

Continue Reading…

Subscribe to read the entire article


Buy this Article as a PDF