Divalproex Treatment of Disruptive Adolescents: A Report of 10 Cases

Article Abstract

Background: To report an open trial of divalproex sodium in 10 adolescents with chronic temper outbursts and mood lability.

Method: Ten adolescents meeting screening criteria for chronic temper outbursts and mood lability were followed for 5 consecutive weeks on open divalproex sodium treatment. Temper outburst frequency and mood swings severity at pretreatment and posttreatment were compared by using paired t tests. Subjects continued to be followed to judge persistence of response.

Results: All subjects showed clear improvement at 5 weeks and maintained it during follow-up while taking medication. Rapid relapse and recovery occurred in 5 of 6 patients who discontinued and then resumed medication.

Conclusion: Divalproex sodium may be helpful in teenagers who have explosive tempers and severe mood swings, and benefits may generalize to school and family life.

Volume: 58

Quick Links: Child and Adolescent , Populations

Continue Reading…

Subscribe to read the entire article


Buy this Article as a PDF

Sign-up to stay
up-to-date today!


Already registered? Sign In

Original Research

Epidemiology of Treatment-Resistant Depression in the United States

This study used 2 insurance databases to estimate the prevalence of treatment-resistant depression among US patients with...