Abstract
Objective: The objective of this study was to investigate potential associations between bariatric surgery and new onset mental health diagnoses and emergent psychiatric care utilization.
Methods: This was an observational retrospective cohort study. Patients without a history of mental health diagnoses who underwent bariatric surgery between 2010-2016 were matched to patients who were eligible for but did not undergo bariatric surgery on demographic, body mass index (BMI), and comorbidity burden at baseline (date of surgery for cases and matching date for controls). Outcomes of new onset mental health diagnoses after baseline and emergent care utilization were measured in 2-year increments between baseline (ranged from 2010 to 2016) until the end of follow-up (December 31, 2021) to assess changes in risk over time.
Results: The surgical group had lower risk of a new onset mental health diagnosis in the first 2 years (hazard ratio [HR]: 0.82, 95% CI, 0.76–0.88) and approximately 20% higher risk in years 4–8 of follow-up than the control group (years 4–6 HR: 1.22, 95% CI, 1.09–1.36; years 6–8 HR: 1.19, 95% CI, 1.03–1.39). However, emergent psychiatric service utilization did not differ between the groups during follow-up. Utilization was associated with a higher BMI (HR: 1.03, 95% CI, 1.02–1.04) and higher comorbidity burden (HR: 1.43, 95% CI, 1.37–1.49) at baseline.
Conclusions: Bariatric surgery may have a delayed impact on new onset mental health diagnoses, with surgical patients having higher risk of diagnoses than their nonsurgical counterparts 4–8 years following surgery. Despite these increases, there was no change in emergent psychiatric service utilization.
J Clin Psychiatry 2025;86(4):25m15806
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References (40)
- Centers for Disease Control and Prevention. Prevalence of Obesity and Severe Obesity Among Adults: United States, 2017-2018. Centers for Disease Control and Prevention; 2020. Accessed July 15, 2024. https://www.cdc.gov/nchs/products/databriefs/db360.htm.
- National Institute of Mental Health. Prevalence of Any Mental Illness. National Institute of Mental Health; 2022. Accessed July 15, 2024. https://www.nimh.nih.gov/health/statistics/mental-illness.
- Avila C, Holloway AC, Hahn MK, et al. An overview of links between obesity and mental health. Curr Obes Rep. 2015;4(3):303–310. PubMed CrossRef
- Giulietti C, Menculini G, Brufani F, et al. Psychiatric comorbidity in bariatric surgery: a retrospective study in a general hospital. Psychiatr Danub. 2021;33(suppl 9):75–79. PubMed
- Dubern B, Mosbah H, Pigeyre M, et al. Rare genetic causes of obesity: diagnosis and management in clinical care. Ann Endocrinol. 2022;83(1):63–72. PubMed CrossRef
- Courcoulas AP, Daigle CR, Arterburn DE. Long term outcomes of metabolic/ bariatric surgery in adults. BMJ. 2023;383:e071027. PubMed CrossRef
- Morledge MD, Pories WJ. Mental health in bariatric surgery: Selection, access, and outcomes. Obesity. 2020;28(4):689–695. PubMed CrossRef
- Adamowicz JL, Salwen JK, Hymowitz GF, et al. Predictors of suicidality in bariatric surgery candidates. J Health Psychol. 2016;21(9):1992–1998. PubMed CrossRef
- Bhatti JA, Nathens AB, Thiruchelvam D, et al. Self-harm Emergencies after bariatric surgery: a population-based cohort study. JAMA Surg. 2016;151(3):226–232. PubMed CrossRef
- Järvholm K, Olbers T, Peltonen M, et al. Depression, anxiety, and suicidal ideation in young adults 5 years after undergoing bariatric surgery as adolescents. Eat Weight Disord. 2021;26:1211–1221. PubMed
- Järvholm K, Karlsson J, Olbers T, et al. Characteristics of adolescents with poor mental health after bariatric surgery. Surg Obes Relat Dis. 2016;12(4):882–890. PubMed CrossRef
- Lent MR, Avakoff E, Hope N, et al. Clinical characteristics of Roux-en-Y gastric bypass patients with death from accidental overdose or intentional self-harm: a descriptive study. Obes Surg. 2018;28(11):3531–3537. PubMed CrossRef
- Shelby SR, Labott S, Stout RA. Bariatric surgery: a viable treatment option for patients with severe mental illness. Surg Obes Relat Dis. 2015;11(6):1342–1348. PubMed CrossRef
- Thomson L, Sheehan KA, Meaney C, et al. Prospective study of psychiatric illness as a predictor of weight loss and health related quality of life one year after bariatric surgery. J Psychosom Res. 2016;86:7–12. PubMed CrossRef
- Van den Eynde A, Mertens A, Vangoitsenhoven R, et al. Psychosocial consequences of bariatric surgery: two sides of a Coin: a scoping review. Obes Surg. 2021;31(12):5409–5417. PubMed CrossRef
- Troisi A. Emergence of bariatric psychiatry as a new subspecialty. World J Psychiatry. 2022;12(1):108–116. PubMed CrossRef
- Fisher D, Coleman KJ, Arterburn DE, et al. Mental illness in bariatric surgery: a cohort study from the PORTAL network. Obesity (Silver Spring). 2017;25(5):850–856. PubMed CrossRef
- Nepal H, Bhattarai M, Agustin ET. New-onset mania following bariatric surgery. Psychiatry Investig. 2015;12(1):152–154. PubMed CrossRef
- Kovacs Z, Valentin JB, Nielsen RE. Risk of psychiatric disorders, self-harm behaviour and service use associated with bariatric surgery. Acta Psychiatr Scand. 2017;135(2):149–158. PubMed CrossRef
- Morgan DJR, Ho KM, Platell C. Incidence and Determinants of Mental Health Service Use After Bariatric Surgery. JAMA Psychiatry. 2020;77(1):60–67. PubMed CrossRef
- Saeed L, Sharif G, Eda S, et al. Comparative effectiveness of bariatric metabolic surgery versus glucagon-like peptide-1 Receptor agonists on cardiovascular outcomes and mortality: a meta-analysis. Cureus. 2024;16(10):e71684. PubMed CrossRef
- Tobaiqy M. A review of serious adverse events linked with GLP-1 agonists in type 2 diabetes mellitus and obesity treatment. Pharmacol Rep. 2024;76(5):981–990. PubMed CrossRef
- Wilding JPH, Batterham RL, Davies M, et al. Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension. Diabetes Obes Metab. 2022;24(8):1553–1564. PubMed CrossRef
- Arterburn D, Wellman R, Emiliano A, et al. Comparative effectiveness and safety of bariatric procedures for weight loss: a PCORnet cohort study. Ann Intern Med. 2018;169(11):741–750. PubMed CrossRef
- Vokinger KN, Nussli E, Dusetzina SB. Access to GLP-1 weight loss drugs in the US, Canada, Switzerland, and Germany. JAMA Intern Med. 2024;184(9):1002–1004. PubMed CrossRef
- American Society for Metabolic and Bariatric Surgery. Access to Care Fact Sheet [Fact Sheet]. American Society for Metabolic and Bariatric Surgery; 2024. Accessed July 15, 2024. https://asmbs.org/resources/access-to-care-fact-sheet/.
- National Institute of Diabetes and Digestive and Kidney Diseases. Potential Candidates for Weight-loss Surgery [Fact Sheet]. National Institute of Diabetes and Digestive and Kidney Diseases; 2020. Accessed July 15, 2024. https://www.niddk.nih.gov/health-information/weight-management/bariatric-surgery/potential-candidates.
- Shafipour P, Der-Sarkissian JK, Hendee FN, et al. What do I do with my morbidly obese patient? A detailed case study of bariatric surgery in Kaiser Permanente Southern California. Perm J. 2009;13(4):56–63. PubMed CrossRef
- The Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP). Optimal Resources for Metabolic and Bariatric Surgery 2019 Standards-Revised. 2022. Accessed July 15, 2024. https://www.facs.org/qualityprograms/accreditation-and-verification/metabolic-and-bariatric-surgeryaccreditation-and-quality-improvement-program/standards/
- Coleman KJ, Huang Y-C, Hendee F, et al. Three-year weight outcomes from a bariatric surgery registry in a large integrated healthcare system. Surg Obes Relat Dis. 2014;10(3):396–403. PubMed CrossRef
- Koebnick C, Langer-Gould AM, Gould MK, et al. Sociodemographic characteristics of members of a large, integrated health care system: comparison with US Census Bureau data. Perm J. 2012;16(3):37–41. PubMed CrossRef
- Pedroza C, Truong V. Estimating relative risks in multicenter studies with a small number of centers—which methods to use? A simulation study. Trials. 2017;18(1):512. PubMed CrossRef
- Chen W, Shi J, Qian L, et al. Comparison of robustness to outliers between robust Poisson models and log-binomial models when estimating relative risks for common binary outcomes: a simulation study. BMC Med Res Methodol. 2014;14:82. PubMed CrossRef
- Miller-Matero LR, Yeh HH, Ahmedani BK, et al. Suicide attempts after bariatric surgery: comparison to a nonsurgical cohort of individuals with severe obesity. Surg Obes Relat Dis. 2023;19(12):1458–1466. PubMed CrossRef
- Youssef A, Keown-Stoneman C, Maunder R, et al. Differences in physical and mental health-related quality of life outcomes 3 years after bariatric surgery: a group-based trajectory analysis. Surg Obes Relat Dis. 2020;16(11):1837–1849. PubMed CrossRef
- Melamed OC, Selby P, Taylor VH. Mental health and obesity during the COVID-19 pandemic. Curr Obes Rep. 2022;11(1):23–31. PubMed CrossRef
- Burnatowska E, Surma S, Olszanecka-Glinianowicz M. Relationship between mental health and emotional eating during the COVID-19 pandemic: a systematic review. Nutrients. 2022;14(19):3989. PubMed CrossRef
- Shankar P, Boylan M, Sriram K. Micronutrient deficiencies after bariatric surgery. Nutrition. 2010;26(11–12):1031–1037. PubMed CrossRef
- Anglin RE, Samaan Z, Walter SD, et al. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry. 2013;202:100–107. PubMed CrossRef
- King WC, Chen JY, Mitchell JE, et al. Prevalence of alcohol use disorders before and after bariatric surgery. JAMA. 2012;307(23):2516–2525. PubMed CrossRef