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Educational Activity

Newer Medications for Complicated Depression

Michael E. Thase, MD

Published: September 15, 2009

This CME activity is expired. For more CME activities, visit
Find more articles on this and other psychiatry and CNS topics:
The Journal of Clinical Psychiatry
The Primary Care Companion for CNS Disorders

Article Abstract

Available antidepressant medications are safe and moderately effective for most patients, but their overall efficacy is similar and underwhelming. The most recently developed antidepressants are either stereoisomers or metabolites of older drugs or belong to an existing class of antidepressants. The development of new medications with novel mechanisms of action and increased efficacy is needed to address unmet needs in the pharmacotherapy of depression.

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