This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.


Are Two Antidepressant Mechanisms Better Than One?

Stephen M. Stahl

Published: August 15, 1997

Article Abstract

The classical antidepressants,
namely tricyclic antidepressants
(TCAs) and monoamine oxidase inhibitors, have multiple
pharmacologic mechanisms, but only
those increasing the availability of serotonin
(5-HT) and norepinephrine
(NE) explain antidepressant actions.
Their other actions, such as anticholinergic
properties, are responsible for
side effects.1 This profile has given
rise to the notion that multiple mechanisms
mean "dirty drugs" and that the
best drugs should be "smart bombs"
attacking only a single receptor target.

Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 58

Quick Links: Psychopharmacology

Sign-up to stay
up-to-date today!


Already registered? Sign In

Original Research

Young-Adult Social Outcomes of Attention-Deficit/Hyperactivity Disorder

ADHD that persisted into young-adulthood was associated with poorer outcomes in terms of education, employment, and emotional...