This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Letters to the Editor

Free Drug Fraction Versus Free Drug Concentration

Article Abstract

Letter to the Editor

Sir: In their article on pharmacokinetic considerations in theelderly, DeVane and Pollock present a wealth of valuable informationfor the clinician. However, a small point needs clarification.The authors state—as do many textbooks and articles onthis subject—that an increase in plasma binding proteins in theelderly "can lead to a diminished free concentration of basicdrugs" (italics mine).


Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 61

Quick Links: Psychopharmacology