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Original Articles

Olanzapine Treatment After Clozapine-Induced Granulocytopenia in 3 Patients

J. Randolph Swartz, Jambur Ananth, Michael W. Smith, Karl S. Burgoyne, Rangaswamy Gadasally, and Yoshi Arai

Published: February 28, 1999

Article Abstract

Background:How to best treat psychotic patients who have had past clozapine-induced agranulocytosis or granulocytopenia remains a problem.

Case reports: We report 3 patients with chronic schizophrenia who had previously stopped clozapine due to hematologic side effects. The patients evidenced improvement with olanzapine that equated to 16- to 31-point decreases in rating scale scores during 1-year follow-up without any hematologic abnormalities.

Conclusion: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects.

Volume: 60

Quick Links: Psychotic Disorders , Schizophrenia and Schizoaffective Disorders

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