Olanzapine Treatment After Clozapine-Induced Granulocytopenia in 3 Patients

J. Randolph Swartz, Jambur Ananth, Michael W. Smith, Karl S. Burgoyne, Rangaswamy Gadasally, and Yoshi Arai

Published: February 28, 1999

Article Abstract

Background:How to best treat psychotic patients who have had past clozapine-induced agranulocytosis or granulocytopenia remains a problem.

Case reports: We report 3 patients with chronic schizophrenia who had previously stopped clozapine due to hematologic side effects. The patients evidenced improvement with olanzapine that equated to 16- to 31-point decreases in rating scale scores during 1-year follow-up without any hematologic abnormalities.

Conclusion: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects.

Volume: 60

Quick Links: Psychotic Disorders , Schizophrenia and Schizoaffective Disorders

Continue Reading…

Subscribe to read the entire article

$40.00

Buy this Article as a PDF

Sign-up to stay
up-to-date today!

SUBSCRIBE

Already registered? Sign In

Original Research

Prevalence and Correlates of Obsessive-Compulsive Symptoms in Individuals With Schizophrenia, Schizoaffective Disorder, or Bipolar Disorder

Prevalence and correlates of obsessive-compulsive symptoms and OCD were identified from the case records of over 22,500...

Read More...