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Underlying Mechanisms of Psychosis and Aggression in Patients With Alzheimer’s Disease

Jacobo E. Mintzer, MD

Published: January 7, 2001

Article Abstract

It is well known that serotonergic function is related to aggression. Patients with Alzheimer’s diseaseexhibit aggressive behavior, and alterations in their serotonergic function have been identified.Recent clinical trials involving new antipsychotic agents, such as risperidone, which has both serotonergicand dopaminergic activity, have demonstrated the efficacy and safety of these drugs in treatingthe psychosis and aggressive behavior associated with dementia.

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