Letter to the Editor

Sleep disturbance could be the initial manifestation of bipolar disorder. Here, read the case of a patient with insomnia. Actigraphy detected sleep disturbances occurring during a hypomanic or manic...

Anxiety specialists tend to avoid prescribing stimulants due to potential negative effects; however, their use may be justified in patients who cannot tolerate antidepressants or in those whose ADHD...

Modafinil is indicated to improve wakefulness in adult patients with excessive sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder. Modafinil has been found to induce mania...

Item 9 of the Patient Health Questionnaire (PHQ-9) is a robust predictor of suicide attempt and suicide death. However, it still has a substantial false-negative rate. This study of...

Use of selective serotonin reuptake inhibitors in clinical practice has increased. Early presentation of serotonin syndrome can be vague and easily dismissed. The authors of this report describe a...

Benzodiazepine tolerance after multiple days or weeks has been described—but not within 48 hours. Read this report of a man with catatonia who rapidly developed tolerance to lorazepam in...