Meta-Analysis

Recently published articles about Meta-Analysis

JCP
Pharmacotherapies for Co-Occurring Stimulant Use Disorder and ADHD
Meta-Analysis

Pharmacotherapies for Co-Occurring Stimulant Use Disorder and ADHD

August 31, 2026

Stimulant-based pharmacotherapies, particularly higher-dose methylphenidate and mixed amphetamine salts, were associated with superior outcomes for both stimulant-use indicators and ADHD symptoms.
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JCP
Placebo Effects in Alcohol, Cocaine, and Methamphetamine Use Disorder
Meta-Analysis

Placebo Effects in Alcohol, Cocaine, and Methamphetamine Use Disorder

June 10, 2026

Placebo treatment led to reductions in craving scores across all three disorders, although statistical significance was achieved only in alcohol use disorder.
, , , et al
JCP
Systematic Review and Meta-Analysis of Use of Mood Stabilizers in Adolescents With Nonsuicidal Self-Injury
Meta-Analysis

Systematic Review and Meta-Analysis of Use of Mood Stabilizers in Adolescents With Nonsuicidal Self-Injury

May 18, 2026

Severity of anxiety, depression, impulsivity, and self-injury was significantly reduced following treatment with mood stabilizers.
, , , et al
PCC
Role of tDCS in Autism
Meta-Analysis

Role of tDCS in Autism

March 12, 2026

Transcranial direct current stimulation improves core autism spectrum disorder symptoms, particularly social responsiveness and behavioral regulation, with stimulation of the dorsolateral prefrontal cortex showing the greatest benefit.
, , , et al
JCP
Effectiveness of Peer-Administered Interventions for Perinatal Depression or Anxiety
Meta-Analysis

Effectiveness of Peer-Administered Interventions for Perinatal Depression or Anxiety

December 8, 2025

Peer-administered interventions are effective at improving perinatal depression, with peer-delivered psychotherapies being the most effective.
, , , et al
JCP
Burnout in Psychiatric Doctors Before and After the COVID-19 Pandemic
Meta-Analysis

Burnout in Psychiatric Doctors Before and After the COVID-19 Pandemic

September 29, 2025

The prevalence of burnout was 37.5% prior to the COVID-19 pandemic and 32.0% following the pandemic.
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Recent JCP Articles on Meta-Analysis

JCP
Rapidity of Improvement With Intranasal Esketamine for MDD
Meta-Analysis

Rapidity of Improvement With Intranasal Esketamine for MDD

December 12, 2022

This meta-analysis found that augmenting antidepressants with intranasal esketamine vs placebo was more effective in reducing depression severity at 24 hours and study endpoint.
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JCP
Tools to Detect Suicide Risk
Meta-Analysis

Tools to Detect Suicide Risk

November 16, 2022

More than 20 instruments have been developed to assist in detecting suicide risk in adults. This systematic review used likelihood ratio analysis to determine the diagnostic accuracy of instruments...
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JCP
Prevalence of Bipolar Disorder in Perinatal Women
Meta-Analysis

Prevalence of Bipolar Disorder in Perinatal Women

July 13, 2022

Perinatal women may be at increased risk for bipolar-spectrum mood episodes. This review and meta-analysis aimed to estimate overall prevalence of bipolar disorder and the prevalence and timing of...
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Recent PCC Articles on Meta-Analysis

PCC
Meta-Analysis

Adjunctive Aripiprazole for MDD

June 24, 2021

Given the scarcity of data, the authors of this review systematically synthesized the literature to determine the long-term efficacy and safety of aripiprazole as a maintenance augmenting agent for...
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PCC
Meta-Analysis

Weight Gain in Severe Mental Illness

December 19, 2019

Patients with severe mental illness tend to have a higher prevalence of metabolic disorders. This review updates the current evidence on the effectiveness of add-on medications to treat weight...
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PCC
Meta-Analysis

Gabapentin and Withdrawal in Alcohol Use Disorder

August 22, 2019

While benzodiazepines are considered the standard of care for alcohol withdrawal, gabapentin is a valuable alternative that can also help with cravings and abstinence long term. Read on to...
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Featured Meta-Analysis Research

PCC
The Aftermath of Risking Life and Limb
Rounds in the General Hospital

The Aftermath of Risking Life and Limb

September 15, 2026

Traumatic injuries (often the result of impulsive and thoughtless behaviors) are potent drivers of disability, disfigurement, PTSD, TBIs, mortality, and high health care costs.
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JCP
Lumateperone as Adjunctive Therapy in Patients With Major Depressive Disorder and Anxious Distress
Original Research

Lumateperone as Adjunctive Therapy in Patients With Major Depressive Disorder and Anxious Distress

September 14, 2026

Adjunctive lumateperone 42 mg significantly improved depression and anxiety symptoms in patients with MDD with inadequate antidepressant response and anxious distress
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JCP
Long-Acting Injectable Antipsychotics and Clozapine in Coordinated Specialty Care: Data From EPINET
Original Research

Long-Acting Injectable Antipsychotics and Clozapine in Coordinated Specialty Care: Data From EPINET

September 14, 2026

Data from the EPINET project reveal wide variation in the prescription of LAIs and clozapine across first-episode specialty care clinics.
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JCP
Treating PTSD in Military Populations
Meta-Analysis

Treating PTSD in Military Populations

March 24, 2025

Integrating psychotherapies and pharmacotherapies may address multiple dimensions of PTSD more effectively than monotherapies.
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JCP
Changes in Cognition in Patients With Schizophrenia
Meta-Analysis

Changes in Cognition in Patients With Schizophrenia

September 25, 2024

Only marginal improvements in cognition were seen over time; the greatest were achieved for patients with an illness duration shorter than 10 years.
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PCC
rTMS in Depression, Schizophrenia, and OCD
Meta-Analysis

rTMS in Depression, Schizophrenia, and OCD

September 26, 2023

In treatment-resistant depression, repetitive transcranial magnetic stimulation had higher odds of response and remission rates compared to sham.
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JCP
Omega-3 PUFA Supplements for ADHD
Meta-Analysis

Omega-3 PUFA Supplements for ADHD

August 30, 2023

Although omega-3 polyunsaturated fatty acids (PUFAs) may not improve core symptoms of attention-deficit/hyperactivity disorder, longer-term PUFA supplementation may have potential benefits.
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JCP
Mechanisms of Treatment of Bipolar Disorder and Borderline Personality Disorder: Brain Imaging Research
Meta-Analysis

Mechanisms of Treatment of Bipolar Disorder and Borderline Personality Disorder: Brain Imaging Research

March 27, 2023

Different brain regions were changed with psychotherapy versus medication. The findings may help with predicting treatment efficacy and identifying treatment biomarkers in these disorders.
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JCP
Antipsychotic Dose and Weight Gain
Meta-Analysis

Antipsychotic Dose and Weight Gain

February 8, 2023

Although effects on weight gain have been explored for several antipsychotics, the role of dose in producing these effects has not been widely studied. This meta-analysis examined the association...
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