Major Depressive Disorder (MDD) is a debilitating condition characterized by persistent feelings of sadness, hopelessness, and a lack of interest in daily activities. Understanding its underlying causes and effective treatments is crucial for patient well-being. The Journal of Clinical Psychiatry provides a comprehensive look into MDD, offering evidence-based therapeutic approaches and the latest research findings. Our expert editors ensure content is relevant and actionable, aiding psychiatrists in offering holistic care to those grappling with depression.
Depression and Major Depressive Disorder
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Recently published articles about Depression (MDD)
ASCP Corner
When Do Physical Symptoms After Antidepressant Cessation Reflect Pharmacodynamic versus Non-pharmacodynamic Clinical Phenomena?
August 6, 2026
Focuses on descriptive symptom phenomenology and strategies to minimize discomfort during antidepressant cessation, with possible explanations for unusual, delayed, or protracted symptoms in patients for whom non-pharmacodynamic features may...
Original Research
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Impact of VNS on Suicidal Ideation in Markedly Treatment-Resistant Major Depression: A RECOVER Study Report
July 8, 2026
Findings suggest that active VNS reduces suicidal ideation (SI) and potentially induces SI remission among participants with chronic TRD and baseline SI.
Original Research
Race, Ethnicity, Socioeconomic Status, Clinical Characteristics, and Postpartum Depression in Patients with a History of Depressive Episodes
June 17, 2026
Patients who were non-White and had lower incomes had higher PPD risk. Higher antidepressant dosing before pregnancy, stopping antidepressants during pregnancy, and moderate-severe symptoms early in pregnancy were associated...
Original Research
CBT following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention: The CBT-ENDURE Randomized Trial
May 4, 2026
In patients with major depression and suicidal ideation, adding a 16-week CBT course to esketamine led to greater improvements in suicidal ideation and depression severity than esketamine alone.
